体外模拟胃肠消化阶段地热水中砷的价态变化  

Changes in the Valence State of Arsenic in Geothermal Water During in Vitro Simulated Gastrointestinal Digestion Stage

作　　者：周会东 冯源强 苏思强 李永林 邱豪 ZHOU Huidong;FENG Yuanqiang;SU Siqiang;LI Yonglin;QIU Hao(Central Laboratory of Geological Mineral Exploration and Development Bureau of Xizang Autonomous Region,Lasa 850033,China)

机构地区：[1]西藏自治区地质矿产勘查开发局中心实验室,西藏拉萨850033

出　　处：《食品安全导刊》2024年第18期75-77,81,共4页China Food Safety Magazine

基　　金：西藏自治区自然科学基金项目“模拟胃酸环境下温泉水中砷的形态变化”(XZ202301ZR0010G)。

摘　　要：地热水中的砷具有一定的药用价值,不同价态砷离子(ionic As,iAs)所表现出来的药理性和毒理性区别较大。本文旨在通过体外模拟实验,探究胃肠消化阶段富砷地热水中砷的形态变化情况。结果发现,i AsⅢ/iAsⅤ的浓度比值在胃消化阶段的变化与地热水的饮用量无关。肠消化阶段iAsⅢ与iAsⅤ的浓度比与地热水饮用量呈正相关,这为科学有效评估富砷地热水对人类的医疗价值提供了技术参考。Arsenic in geothermal water has certain medicinal value,and the pharmacological and toxic effects of different valence states of ionic arsenic(iAs)vary greatly.This article aims to explore the morphological changes of arsenic in arsenic rich geothermal water during gastric and intestinal digestion stages through in vitro simulation experiments.The result showed that the concentration ratio of iAsⅢ/iAs V was independent of the amount of geothermal water consumed during the gastric digestion stage.In the intestinal digestion phase,the concentration ratio of iAsⅢto iAsⅤis positively correlated with the amount of geothermal water ingested.This study aims to provide technical references for scientifically and effectively evaluating the medical value of arsenic-rich geothermal water to humans.

关 键 词：富砷地热水 体外模拟 离子价态 消化 

分 类 号：R454[医药卫生—治疗学]