Tryptophan-specific peptide modification through metal-free photoinduced N-H alkylation employing N-aryl glycines  

作　　者：Jianhui Yin Wenjing Huang Changyong Guo Chao Liu Fei Gao Honggang Hu 

机构地区：[1]School of Medicine or Institute of Translation Medicine,Shanghai University,Shanghai 200444,China

出　　处：《Chinese Chemical Letters》2024年第6期316-319,共4页中国化学快报（英文版）

基　　金：the financial support from the National Natural Science Foundation of China(No.22107062);the National Natural Science Foundation of Shanghai(No.21ZR1422600)。

摘　　要：Tryptophan(Trp)carries a unique heteroaromatic indole side chain and plays a critical role in peptide or protein modification.Herein,we have reported a metal-free photoinduced N-H alkylation strategy using N-aryl glycines for specific modification of tryptophan-containing peptides.The robustness of our approach is demonstrated by its wide substrate scope,excellent isolated yields,as well as almost unobservable side effects.Using this highly efficiently metal-free condition,alkylated Trp-containing peptides can be smoothly assembled.This study provides a reliable and practical tool for the chemo-selective modification of various tryptophan containing oligopeptides.

关 键 词：TRYPTOPHAN PEPTIDE MODIFICATION Glycine PHOTOINDUCED 

分 类 号：O629.7[理学—有机化学]