Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition  

作　　者：Chenlu Huang Xinyu Yang Qingyu Yu Linhua Zhang Dunwan Zhu 

机构地区：[1]Tianjin Key Laboratory of Biomedical Materials,Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China

出　　处：《Chinese Chemical Letters》2024年第6期456-461,共6页中国化学快报（英文版）

基　　金：financially supported by National Natural Science Foundation of China(Nos.82172090,82302390 and 82072059);CAMS Innovation Fund for Medical Sciences(Nos.2021-I2M-1-058 and 2022-I2M-1-023);China Postdoctoral Science Foundation(No.2022M720502);Tianjin Municipal Natural Science Foundation(No.22JCQNJC00070);CAMS Union Young Scholars Support Program(No.2022051);Fundamental Research Funds for the Central Universities(No.2019PT320028)。

摘　　要：Due to the heterogeneity of tumors,single phototherapy cannot completely ablate tumors and inhibit tumor metastasis.To overcome these,we formulated targeted and multifunctional polymersomes ABC@ICGIMQ-LHRH(AIRL)that encapsulated Toll-like receptor(TLR)7/8 agonist imiquimod(IMQ)and photosensitizer indocyanine green(ICG)in the hydrophobic layer as well as bubble-generator NH_(4)HCO_(3) in the hydrophilic cavity to inhibit the growth of primary and distant tumors,and prevent tumor metastasis through synergistic photoimmunotherapy.The AIRL polymersomes exhibited uniform and stable size,and high drug encapsulation efficiency,acid/reduction/laser responsiveness,excellent photothermal conversion efficiency,effective reactive oxygen species generation,high tumor accumulation.AIRL could be effectively internalized by dendritic cells(DCs),achieve lysosome escape and enhance DCs maturation.The synergistic photoimmunotherapy via AIRL polymersomes remarkably promoted the differentiation and activation of T cells,elevated strong systemic immune response to eradicate primary tumors and inhibit the growth of distant tumors.Simultaneously,the endurable immunological memory prevented tumor metastasis,which provided a promising nanoplatform for the combination therapy of cancer.

关 键 词：POLYMERSOMES PHOTOTHERAPY Immunotherapy TLR 7/8 agonist Gas-generating 

分 类 号：R313[医药卫生—基础医学] TB383.1[一般工业技术—材料科学与工程]