Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine?Autophagy regulation also works  

作　　者：Yuanyi Zhou Ke Ma Jinfeng Liu Zirun Zheng Bo Hu Yu Meng Zhizhong Li Mingshan Zhu 

机构地区：[1]Postdoctoral Innovation Practice Base,The First and Fifth Affiliated Hospital of Jinan University,Guangzhou 510632,China [2]Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction,The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital),Heyuan 517465,China [3]School of Environment,Jinan University,Guangzhou 511443,China [4]Department of Nephrology,The First Affiliated Hospital of Jinan University,Guangzhou 510632,China

出　　处：《Chinese Chemical Letters》2024年第6期474-479,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.52202240,82270756 and 82000686);the China Postdoctoral Science Foundation(No.2021M701409);the Natural Science Foundation of Guangdong,China(No.2018A030313527);the Basic and Applied Basic Research Foundation of Guangdong Province,China(No.2019A1515010176);the Science and Technology Project of Guangzhou,China(No.202102010133);the Science and Technology Project of Shenzhen,China(No.JCYJ20190808095615389)。

摘　　要：Exploring the therapeutic effect of single atom catalysts beyond reactive oxygen species(ROS)modulation would boost the prosperity of nanomedicine in cancer treatment.Autophagy as a vital therapy target offers new options for the control of renal cell carcinoma(RCC)progression.Herein,Fe single atom-decorated graphene oxide(Fe_(1)-GO)nanosheet is developed to be a feasible autophagy inducer in RCC treatment.With the well-dispersed O-Fe_(1)-O active sites,Fe_(1)-GO kills ACHN cells effectively but maintains acceptable cytotoxicity to the normal podocyte and HK2 ones.In-depth analyses ascribe the inhibition of ACHN cells to the upregulated autophagy instead of the commonly known catalytic ROS generation.The in vivo therapeutic effect of Fe_(1)-GO nanomedicine is also validated by the RCC-bearing BALB/c mice model,realizing an 89% reduction of tumor weight and good biosafety.This work provides new insights into the design of autophagy regulators as well as potential therapeutic strategies for RCC treatment.

关 键 词：Fe single atom AUTOPHAGY Renal cell carcinoma Graphene oxide Cancer therapy 

分 类 号：R73-3[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]