Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications  

作　　者：So Jung Kim Jeongeun Hyun 

机构地区：[1]Institute of Tissue Regeneration Engineering(ITREN),Dankook University,Cheonan,Republic of Korea [2]Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine,Dankook University,Cheonan,Republic of Korea [3]Mechanobiology Dental Medicine Research Center,College of Dentistry,Dankook University,Cheonan,Republic of Korea

出　　处：《Signal Transduction and Targeted Therapy》2024年第5期1781-1783,共3页信号转导与靶向治疗（英文）

基　　金：This study was supported by the National Research Foundation of Korea(grant number 2021R1C1C1003904 to J.H.)。

摘　　要：The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTL14 in mitigating the progression of metabolic dysfunction-associated fatty liver disease(MAFLD).1 In this study,Wang et al.elucidated the downregulation of METTL14 in hepatocytes from both MAFLD patients and high-fat diet(HFD)-induced MAFLD mouse models,underscoring its pivotal role in maintaining hepatic lipid and redox homeostasis in normal livers.

关 键 词：liver HOMEOSTASIS al. 

分 类 号：R575.5[医药卫生—消化系统]