靶向MYC基因抗肿瘤研究进展  

Advances in Anti-Tumor Research Targeting MYC Gene

作　　者：徐冶[1,2] XU Ye(Jilin Medical University,Jilin City,Jilin Province 132013;Laboratory of Tumor Targeted Therapy and Translational Medicine,Jilin City,Jilin Province 132013,China)

机构地区：[1]吉林医药学院,吉林吉林132013 [2]肿瘤靶向治疗与转化医学实验室,吉林吉林132013

出　　处：《吉林医药学院学报》2024年第4期241-245,共5页Journal of Jilin Medical University

摘　　要：MYC是研究最为广泛的原癌基因之一,属于碱性螺旋-环-螺旋亮氨酸拉链(bHLH-Zip)DNA结合蛋白超家族,通过与MAX形成MYC-MAX异二聚体发挥功能。MYC影响蛋白质合成、细胞黏附、增殖、分化、细胞周期、代谢、细胞凋亡和血管形成等多种生物学过程。因其结构与位置的特殊性,难以直接靶向,针对MYC的治疗策略是研究的热点,本文将系统回顾MYC基因的结构、功能和其抑制剂的研究进展,为靶向MYC治疗肿瘤提供新思路。MYC is one of the most widely studied proto-oncogenes.It belongs to the basic helix-loop-helix leucine zipper(bHLH-Zip)DNA-binding protein superfamily and functions by forming MYC-MAX heterodimer.MYC affects a variety of biological processes,such as protein synthesis,cell adhesion,proliferation,differentiation,cell cycle,metabolism,apoptosis,and angiogenesis.Due to its special structure and location,it is difficult to directly target MYC.The therapeutic strategy for MYC is the focus of research.This article will systematically review the structure and functions of MYC gene and the research progress of its inhibitors,to provide new options for the treatment of tumor by targeting MYC.

关 键 词：MYC基因 抑制剂 靶向治疗 

分 类 号：R730.5[医药卫生—肿瘤]