秀丽隐杆线虫在真菌毒素毒理学研究中的应用进展  

Progress in the application of Caenorhabditis elegans in the toxicological research of mycotoxins

作　　者：周湘宜 胡梁斌 莫海珍 周威[2] 姚丽姗 徐丹[1] ZHOU Xiangyi;HU Liangbin;MO Haizhen;ZHOU Wei;YAO Lishan;XU Dan(School of Food Science and Engineering,Shaanxi University of Science and Technology,Xi′an 710021,China;School of Food Science,Henan Institute of Science and Technology,Xinxiang 453000,China)

机构地区：[1]陕西科技大学食品科学与工程学院,陕西西安710021 [2]河南科技学院食品学院,河南新乡453000

出　　处：《河南工业大学学报（自然科学版）》2024年第3期1-8,共8页Journal of Henan University of Technology：Natural Science Edition

基　　金：国家自然科学基金面上项目(32272278);陕西省创新能力支撑计划项目(2023-CX-TD-61)。

摘　　要：真菌毒素是由丝状真菌产生的有毒次级代谢产物,可通过食物链累积传递,由于其稳定性强,难以消减,对消费者造成了极高的暴露风险,严重影响婴幼儿等人群的成长发育。因此,真菌毒素毒理学已从实质性靶器官的毒性研究扩展到长期高暴露对生命早期人群的毒性研究。秀丽隐杆线虫因其具有发育快、基因与人类高度同源、遗传背景清晰等优点,已成为评估外源性毒素发育毒性的首选模式生物。从生长发育毒性、生殖发育毒性和神经发育毒性3个角度综述了秀丽隐杆线虫在真菌毒素毒理学研究中的应用,重点分析了真菌毒素对幼虫期秀丽隐杆线虫的发育毒性效应,探究了真菌毒素的发育毒性分子机制,有助于建立标准化的真菌毒素毒理学评价模型,为真菌毒素食源性干预剂的筛选提供科学依据。Mycotoxins are toxic secondary metabolites produced by filamentous fungi,which can be accumulated and transmitted through the food chain.Due to their strong stability and difficulty to reduce,high exposure risk to consumers,as well as affect the growth and development of populations such as infants and young children,mycotoxicology research has expanded from the toxicity studies on substantial target organs to long-term toxicity studies on early life populations with high exposure.The Caenorhabditis elegans(C.elegans),with its rapid development,high genetic homology to humans,and clear genetic background,has become the preferred model organism for evaluating the toxicity and toxicological mechanisms of exogenous toxins.To provide a theoretical basis for a comprehensive understanding of the toxic effects and mechanisms of mycotoxins,this article reviews the applications of C.elegans in mycotoxins toxicology research,from the perspectives of developmental toxicity,reproductive toxicity,and neurodevelopmental toxicity.In detail,this review focuses on analyzing the developmental toxic effects of mycotoxins on the larval stage of C.elegans and exploring the molecular mechanisms of developmental toxicity.This review will contribute to the establishment of accurate toxicological evaluation model for mycotoxins and offer a scientific basis for the screening of food-origin toxin intervention agents.

关 键 词：真菌毒素 秀丽隐杆线虫 生长发育毒性 生殖发育毒性 神经发育毒性 

分 类 号：TS201.3[轻工技术与工程—食品科学]