后生元的功能成分及生物活性研究进展  

Research progress on functional components and biological activities of postbiotics

作　　者：李韩 宇光海[1] 潘龙 廖爱美 惠明[1] 黄继红[1,2,3,4] 侯银臣 LI Han;YU Guanghai;PAN Long;LIAO Aimei;HUI Ming;HUANG Jihong;HOU Yinchen(College of Biological Engineering,Henan Key Laboratory of Wheat Bioprocessing and Nutritional Function,College of Bioengineering,Henan University of Technology,Zhengzhou 450001,China;Food Laboratory of Zhongyuan,Luohe 462300,China;School of Agriculture,Henan University,Kaifeng 475001,China;School of Food and Pharmacy,Collaborative Innovation Center of Functional Food Green Manufacturing Henan Province,Xuchang University,Xuchang 461000,China;School of Food and Bioengineering,Henan University of Animal Husbandry and Economy,Zhengzhou 450046,China)

机构地区：[1]河南工业大学生物工程学院,河南省小麦生物加工与营养功能重点实验室,河南郑州450001 [2]中原食品实验室,河南漯河462300 [3]河南大学农学院,河南开封475001 [4]许昌学院食品与药学院,功能食品绿色制造河南省协同创新中心,河南许昌461000 [5]河南牧业经济学院食品与生物工程学院,河南郑州450046

出　　处：《河南工业大学学报（自然科学版）》2024年第3期132-142,共11页Journal of Henan University of Technology：Natural Science Edition

基　　金：河南省中央引导地方科技发展资金项目(Z20221341069);河南省重大科技专项(221100110700)。

摘　　要：后生元是指对宿主健康有益的无生命微生物和(或)其成分制剂,包括菌体代谢产物(如短链脂肪酸、胞外多糖、有机酸、蛋白质等)以及灭活菌体和菌体的成分(如肽聚糖、磷壁酸、细胞壁多糖、细胞表层蛋白等)。与益生菌相比,后生元的安全性和稳定性更高,可以避免活菌转移耐药基因的潜在风险,更加有利于储存和生产。综述了后生元的功能性成分及生物活性、植物基后生元组分及生物活性、后生元的产业现状与趋势,详细介绍了后生元成分在抗氧化、免疫调节、抗炎等方面的研究进展,尤其关注了植物基后生元组分,并通过对后生元市场未来发展趋势的展望阐述了后生元安全性研究和评价体系建立的必要性,旨在为后生元的深入研究及其在食品、生物医药等领域的应用开发提供参考。Postbiotics are preparations of inanimate microorganisms and/or their constituents that benefit the host′s health.These constituents include inactivated bacteria and their metabolites(e.g.,peptidoglycans,teichoic acids,extracellular polysaccharides,surface layer proteins,etc.)as well as bacteria′s metabolites(e.g.,short-chain fatty acids,extracellular polysaccharides,organic acids,proteins,etc.).Postbiotics are safer and more stable than probiotics,and they can prevent the transmission of drug-resistant genes from living bacteria.They are also more suitable for production and storage.This study combines the most recent domestic and international research contents to elaborate on the postbiotic research hotspots,functional components and bioactivities of postbiotics,plant-based postbiotics components and bioactivities,and the industrial status and trends of postbiotics.It introduces in detail the progress of the research on the components of postbiotics in the areas of antioxidant,immunomodulation and anti-inflammation that have been researched,with a particular focus on plant-based postbiotics components.Through the outlook of the future development trend of the postbiotic market,the necessity of establishing the safety research and evaluation system of postbiotics is elaborated.This review will provide a reference for in-depth research on postbiotics and their industrialization and development in the field of food biomedicine and other fields.

关 键 词：后生元 生物活性 灭活益生菌 代谢产物 植物基发酵食品 

分 类 号：TS201.2[轻工技术与工程—食品科学]