Boeravinone B ameliorates allergic nasal inflammation by modulating the GATA-3/T-bet signaling pathway in a mouse model of allergic rhinitis  

作　　者：Ben Ye Ji-Zhe Wang 

机构地区：[1]Department of Otorhinolaryngology,Second Hospital of Dalian Medical University,Dalian,116000,China [2]Department of Otorhinolaryngology,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan,250000,China

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第6期245-252,共8页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible mechanism.Methods:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone B.Nasal mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LTC-4,myeloperoxidase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,antioxidant parameters,and allergen-specific cytokines were assessed.Results:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(P<0.05).It also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GATA-3,and ROR-γwhile enhancing the level of T-bet.Conclusions:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.

关 键 词：Allergic reaction Boeravinone B Oxidative stress INFLAMMATION OVALBUMIN 

分 类 号：R285.5[医药卫生—中药学]