Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The Study of Muscle,Mobility and Aging(SOMMA)  

作　　者：Yujia(Susanna)Qiao Terri L.Blackwell Peggy M.Cawthon Paul M.Coen Steven R.Cummings Giovanna Distefano Samaneh Farsijani Daniel E.Forman Bret H.Goodpaster Stephen B.Kritchevsky Theresa Mau Frederico G.S.Toledo Anne B.Newman Nancy W.Glynn 

机构地区：[1]Department of Epidemiology,School of Public Health,University of Pittsburgh,Pittsburgh,PA 15261,USA [2]San Francisco Coordinating Center,California Pacific Medical Center Research Institute,San Francisco,CA 94143,USA [3]Department of Epidemiology and Biostatistics,University of California,San Francisco,CA 94143,USA [4]Translational Research Institute,AdventHealth,Orlando,FL 32804,USA [5]Department of Medicine(Geriatrics and Cardiology),University of Pittsburgh,and Geriatrics,Research,Education,and Clinical Center(GRECC),VA Pittsburgh Healthcare System,Pittsburgh,PA 15261,USA [6]Department of Internal Medicine,Section on Gerontology and Geriatric Medicine,Wake Forest School of Medicine,Winston-Salem,NC 27109,USA [7]Division of Endocrinology and Metabolism,Department of Medicine,University of Pittsburgh,Pittsburgh,PA 15261,USA

出　　处：《Journal of Sport and Health Science》2024年第5期621-630,共10页运动与健康科学（英文）

基　　金：supported by funding from the National Institute on Aging(NIA,R01 AG059416);funded in part by the NIA Claude D.Pepper Older American Independence Centers at the University of Pittsburgh(P30 AG024827);Wake Forest University(P30 AG021332);the Clinical and Translational Science Institutes,funded by the National Center for Advancing Translational Science,at Wake Forest University(UL1 TR001420)。

摘　　要：Background:Skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older adults.Yet,many studies reporting these effects were based on self-reported PA or structured exercise interventions.Therefore,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(SB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle energetics.Methods:As part of the Study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±SD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed using a wrist-worn ActiGraph GT9X over 7 days.Self-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for Seniors(CHAMPS)questionnaire.Linear regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary behavior.As a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle energetics.Results:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOS and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(p<0.05).Light activity was not associated with maxOXPHOS or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOS and0.006 mM/s lower ATP_(max)(p<0.05).Only associ

关 键 词：AGING Exercise MITOCHONDRIA 

分 类 号：TG1[金属学及工艺—金属学]