“食药同源”的生物学原理  

Biological principles of"food and medicine homologous"

作　　者：丁劲文 迟湘胤 张玉 王璐璐[2] 蒋建东 林媛[1] DING Jin-wen;CHI Xiang-yin;ZHANG Yu;WANG Lu-lu;JIANG Jian-dong;LIN Yuan(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,天然药物活性物质与功能国家重点实验室,北京100050 [2]中国医学科学院、北京协和医学院医药生物技术研究所,北京100050

出　　处：《药学学报》2024年第6期1509-1518,共10页Acta Pharmaceutica Sinica

基　　金：中国工程院战略研究与咨询项目(2023-XZ-88);中国医学科学院医学与健康科技创新工程重大协同创新项目(2022-I2M-1-016).

摘　　要：随着社会快速发展以及“健康中国”战略的提出,人民群众对生活质量和健康水平的需求日益增长,“食药同源”的理念也逐渐受到人们重视。“食药同源”概念在我国历史悠久,是我国传统医学中食疗、药膳、养生及治未病等多种思想的凝练。“食药同源”具有坚实的科学基础,其活性物质成分具有多种类、多机制和多靶点等特点,经过口服吸收及代谢转化后,发挥其生物学效应,而且安全性好。本文从化合物、生物大分子及肠道菌群与肠道这三方面解析多种“食药同源”物质发挥药理活性的化学基础及生物学原理;并以肠道菌群为主要研究内容,重点分析了几个经典“食药同源”物质的生物学原理;论述了研究“食药同源”的科学意义。本文旨在从现代医药学的角度来理解和探索“食药同源”这一传统理念的科学内涵,为新药研发及人类健康发展提供理论参考。With the rapid society development and broad recognition of"Healthy China",the demands for good life and health are increasing.Accordingly,the concept of"food and medicine homologous"have been attractive.The concept of"food and medicine homologous"has a long history in China,and is an essence of various ideas in traditional Chinese medicine,such as diet therapy,medicated diet,regimen and preventive treatment of disease,representing an important field in health science.Many studies have found that the active ingredients of"food and medicine homologous"substances are multiple types,multiple mechanisms and multiple targets,exerting their biological effects after oral administration and chemical or metabolic transformation.In this review,the chemical basis and biological principles of various"food and medicine homologous"substances were summarized as compounds,biological macromolecules and intestinal flora.By focusing on the intestinal flora,we discussed the detailed biological principles of several classic"food and medicine homologous"substances.The scientific significance of"food and medicine homologous"concept were also discussed.This review explores the concept of"food and medicine homologous"from the perspective of modern medicine,in order to provide insights for future drug development and human health.

关 键 词：食药同源 治未病 肠道菌群 化学基础 药理作用 标本兼治 

分 类 号：R966[医药卫生—药理学]