Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation  

作　　者：Yixi Yang Cheng Zhang Yuan Jiang Yijun He iawei Cai Lin Liang Zhaohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang Zhiyong Zhang 

机构地区：[1]Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University,Guangdong Province Engineering Research Center for Biomedical Engineering,State Key Laboratory of Respiratory Disease,Department of Orthopaedic Surgery,Medical Technology and Related Equipment Research for Spinal Injury Treatment,City Key Laboratory,The Third Affliated Hospital of Guangzhou Medical University,School of Biomedical Engineering,Guangzhou MedicalUniversity,Guangzhou,Guangdong510150,P.R.China [2]Department of Osteoarthropathy and Sports Medicine,Panyu Central Hospital,Guangzhou 511400,P.R.China

出　　处：《Regenerative Biomaterials》2024年第2期88-99,共12页再生生物材料(英文版)

基　　金：The research conducted in this study received financial assis-tance from the National Natural Science Foundation of China(NSFC)(81772354,81902189,82072415 and 82072409);the Clinical Innovation Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(No.2018GZR0201001);the Science and Technology Innovation Project of Foshan City(No.1900000025);the Science Technology Project of Guangzhou City(No.2019ZD15);Panyu Key Medical and Health Projects of Science and Technology Planning(2022-204-101);Natural Science Foundation of Guangdong Province(2019A1515012020);Guangdong Basic and Applied Basic Research Foundation(Nos 2022A1515011982,2020A1515111046 and 2020A1515110343);the Collegiate Innovation and National Young Thousand Talent Schemne to Z.-Y.Z.

摘　　要：Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface healing.Extensive clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive protocol.Therefore,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical management.Throughout the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to diabe-tes.We demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory microenviron-ment.promote larizationand.ultimatel accelerateskin healing in diabetic mice.The results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic conditions.This novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关 键 词：MACROPHAGE diabetic wound post-traumatic inflammation cytokine-induced killer cells VASCULARIZATION 

分 类 号：R73[医药卫生—肿瘤]