分子对接在筛选抗宫颈癌药物中的研究进展  

Research progress of molecular docking in screening anti-cervical cancer drugs

作　　者：王丹 张文艳 罗仁洁 陈元静 韩雪[2] 曲波[2] 冯石芳[2] 聂夏子 刘会玲[2] WANG Dan;ZHANG Wenyan;LUO Renjie;CHEN Yuanjing;HAN Xue;QU Bo;FENG Shifang;NIE Xiazi;LIU Huiling(The First Clinical College of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu,China;Department of Gynecology,Gansu Provincial People's Hospital,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院妇科,甘肃兰州730000

出　　处：《中国临床药理学与治疗学》2024年第8期955-960,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金地区基金(82260557);新锐肿瘤支持治疗课题研究公益项目(cphcf-2022-012);甘肃省自然科学基金(22JR5RA693)。

摘　　要：宫颈癌是最常见的妇科恶性肿瘤之一,在淋巴结转移和远处转移的情况下,五年生存率显著下降,因此研发新型抗宫颈癌药物对于治疗宫颈癌有重大的意义。分子对接技术是计算机辅助药物设计技术中最常用的研究方法之一,在筛选药物有效成分、发现药物作用于肿瘤的靶点以及探索抗肿瘤药物的作用机制中被广泛应用。本文将分子对接技术在抗宫颈癌药物筛选、抗肿瘤靶标确定方面以及抗宫颈癌作用机制等方面作一综述,为筛选抗宫颈癌药物及新药研发提供更充分的理论依据。Cervical cancer is one of the most common gynecological malignant tumors,the fiveyear survival rate decreased significantly in the case of lymph node metastasis and distant metastasis,so the development of new anti-cervical cancer drugs is of great significance for the treatment of cervical cancer.Molecular docking technology is one of the most commonly used research methods in computer aided drug design,which is widely used in screening the effective components of drugs,finding the targets of drugs acting on tumors and exploring the mechanism of antineoplastic drugs.This paper reviews the molecular docking technology in the screening of anti-cervical cancer drugs,the determination of anti-tumor targets and the mechanism of anti-cervical cancer,in order to provide more sufficient theoretical basis for the screening of anti-cervical cancer drugs and new drug research and development.

关 键 词：宫颈癌 分子对接 虚拟筛选 靶标蛋白 作用机制 

分 类 号：R737.33[医药卫生—肿瘤]