GCGR:novel potential therapeutic target for chronic kidney disease  

作　　者：Yan Hu Hao Huang Rong Xiang 

机构地区：[1]Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE,State Key Laboratory of Biotherapy,West China Second University Hospital,Sichuan University,Chengdu 610041,China [2]Department of Nephrology,Xiangya Hospital Central South University,Changsha 410008,China [3]Department of Cell Biology,School of Life Sciences,Central South University,Changsha 410013,China [4]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China [5]Hunan Key Laboratory of Organ Fibrosis,Central South University,Changsha 410013,China

出　　处：《Science China(Life Sciences)》2024年第7期1542-1544,共3页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(82003102,82300787,82170598);Hunan Provincial Key Field R&D Plan Project(2022SK2034);Natural Science Foundation of Hunan Province(2022JJ30058,2021JJ40992);the Youth Science Foundation of Xiangya Hospital(2021Q11)。

摘　　要：The kidney,a central regulator of systemic homeostasis essential for human health,plays a vital role in various metabolic pathways,including fatty acid metabolism,gluconeogenesis,glycolysis,and mitochondrial metabolism.Chronic kidney disease(CKD)manifests as a progressive decline in renal function,marked by reduced glomerular filtration rate(GFR)or persistent kidney damage persisting for more than three months.

关 键 词：KIDNEY METABOLISM HOMEOSTASIS 

分 类 号：R692[医药卫生—泌尿科学]