Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease  

作　　者：Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen Qianxing Zhuang 

机构地区：[1]Department of Physiology,School of Medicine,Nantong University,Nantong,Jiangsu Province,China [2]Department of Neurosurgery,Huashan Hospital,Shanghai Medical College,Fudan University,Shanghai,China [3]National Center for Neurological Disorders,Shanghai,China [4]Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration,Shanghai,China [5]State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Institute of Brain Science,Fudan University,Shanghai,China

出　　处：《Neural Regeneration Research》2025年第6期1628-1643,共16页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.31771143 (to QZ);Shanghai Municipal Science and Technology Major Project,ZJ Lab;Shanghai Center for Brain Science and Brain-Inspired Technology,No.2018SHZDZX01 (to LC);Shanghai Zhou Liangfu Medical Development Foundation “Brain Science and Brain Diseases Youth Innovation Program”(to ZQ)。

摘　　要：The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the composition of the globus pallidus neurons, th

关 键 词：ANXIETY basal ganglia BRADYKINESIA deep brain stimulation DEPRESSION globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease 

分 类 号：R742.5[医药卫生—神经病学与精神病学]