BRADYKINESIA

作品数：8被引量：13H指数：2
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相关领域：医药卫生生物学更多>>
相关期刊：《World Journal of Gastroenterology》《Translational Neurodegeneration》《Advances in Parkinson's Disease》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Human stem cell-based cell replacement therapy for Parkinson’s disease:Enhancing the survival of postmitotic dopamine neuron grafts
《Neural Regeneration Research》2026年第2期689-690,共2页Tae Wan Kim 
supported by the DGIST start-up funds from the Ministry of Science and ICT(2024010330);a National Research Foundation of Korea(NRF)grant funded by the Korea Government(MSIT)(No.RS-2024-00351442)(to TWK).
Parkinson’s disease(PD)is the second most common neurodegenerative disorder.The progressive degeneration of dopamine(DA)producing neurons in the midbrain is the pathological hallmark,which leads to debilitating motor...
关键词：neuronal survival cell replacement therapy dopamine neurons human stem cells bradykinesiadrug treatmentssuch Parkinsons disease neurodegenerative disorderthe parkinson s disease pd 
Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease
《Neural Regeneration Research》2025年第6期1628-1643,共16页Yimiao Jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan Jiang Wangrui Yuan Xin Cao Liang Chen Qianxing Zhuang 
supported by the National Natural Science Foundation of China,No.31771143 (to QZ);Shanghai Municipal Science and Technology Major Project,ZJ Lab;Shanghai Center for Brain Science and Brain-Inspired Technology,No.2018SHZDZX01 (to LC);Shanghai Zhou Liangfu Medical Development Foundation “Brain Science and Brain Diseases Youth Innovation Program”(to ZQ)。
The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in th...
关键词：ANXIETY basal ganglia BRADYKINESIA deep brain stimulation DEPRESSION globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease 
Activation and polarization of striatal microglia and astrocytes are involved in bradykinesia and allodynia in early-stage parkinsonian mice被引量：1
《Fundamental Research》2024年第4期806-819,共14页Xue Zhang Zi-Lin Shen Ya-Wei Ji Cui Yin Cheng Xiao Chunyi Zhou 
the National Natural Science Foundation of China(81971038,82071231,82171235,82271293,81870891);the Fund for Jiangsu Province Specially-Appointed Professor(C.X.,C.Z.);the Natural Science Foundation of Jiangsu Province(BK20211349);the Leadership Program in Xuzhou Medical University(JBGS202203).
In addition to the cardinal motor symptoms,pain is a major non-motor symptom of Parkinson's disease(PD).Neuroinflammation in the substantia nigra pars compacta and dorsal striatum is involved in neurodegeneration in P...
关键词：Parkinson's disease Dopaminergic system STRIATUM MICROGLIA ASTROCYTES Substantia nigra pars compacta 
Epalrestat improves motor symptoms by reducing oxidative stress and inflammation in the reserpine induced mouse model of Parkinson’s disease被引量：6
《Animal Models and Experimental Medicine》2020年第1期9-21,共13页Md.Mahbubur Rahman Rupali Rani Chakraborti Md.Abdullah Potol Ariful Haque Abir Ozayra Sharmin Mahabub Alam Md.Fazlur Rahman Khan Rownock Afrin Humayra Jannat Rasiqh Wadud Zaki Farhad Habib 
We thank Ms Fahmida Zaman for her initial intellectual support for this project;We are grateful to Ms Noshin Noorjahan for her editorial support for our manuscript.Department of Pharmaceutical Sciences at North South University provided the Laboratory space,including the equipment and basic reagents necessary to conduct this project.
Background:Parkinson's disease(PD)is a progressive neurodegenerative disorder affecting a large number of elderly people worldwide.The current therapies for PD are symptom-based;they do not provide a cure but improve ...
关键词：BRADYKINESIA EPALRESTAT GLUTATHIONE OXIDATIVE-STRESS Parkinson's disease 
Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation被引量：3
《Translational Neurodegeneration》2018年第1期167-174,共8页Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen 
This work was supported by the National Natural Science Foundation of China(grant numbers.81430022,81771374).
Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objecti...
关键词：Parkinson’s DISEASE BRADYKINESIA EVOLUTIONARY algorithms Objective assessment CLINICAL validation 
Parkinson Kinetic Graph: Are Motor Fluctuations in Parkinson Disease Related with Disease Duration?被引量：1
《Advances in Parkinson's Disease》2018年第1期1-6,共6页Esther Berghuis Barbera Van Harten Mirjam Van Kesteren-Biegstraaten Wijnand Rutgers Nicolaas Verwey 
Introduction: The Parkinson’s KinetiGraph (PKG) is a digital measurement system for motor fluctuations (FS). The aim of this study is to investigate whether FS, measured by the PKG, are associated with disease durati...
关键词：Late Stage PARKINSON DISEASE LEVODOPA DISEASE Duration Fluctuations DYSKINESIA BRADYKINESIA 
Voltage adjustment improves rigidity and tremor in Parkinson's disease patients receiving deep brain stimulation被引量：1
《Neural Regeneration Research》2018年第2期347-352,共6页Shao-hua Xu Chao Yang Wen-biao Xian Jing Gu Jin-long Liu Lu-lu Jiang Jing Ye Yan-mei Liu Qi-yu Guo Yi-fan Zheng Lei Wu Wan-ru Chen Zhong pei Ling Chen 
supported by the Science and Technology Foundation of Guangdong Province of China,No.2014A030304019;the Natural Science Foundation of Guangdong Province of China,No.2015A030313164
Deep brain stimulation of the subthalamic nucleus is recognized as the most effective treatment for moderate and advanced Parkinson＇s disease. Programming of the stimulation parameters is important for maintaining th...
关键词：nerve regeneration deep brain stimulation Parkinson＇s disease subthalamic nucleus VOLTAGE pulse width frequency TREMOR RIGIDITY BRADYKINESIA axial symptoms neural regeneration 
Multidimensional assessment of neuro-psychiatric symptoms in patients with low-grade hepatic encephalopathy: A clinical rating scale被引量：1
《World Journal of Gastroenterology》2005年第37期5893-5898,共6页Sergei Mechtcheriakov Ivo W Graziadei André Kugener Julia Wiedemann Chantal Galbavy Hartmann Hinterhuber Josef Marksteiner Wolfgang Vogel 
AIM： To evaluate the feasibility of a new clinical rating scale for a standardized assessment of cirrhosis-associated neuro-psychiatric symptoms. METHODS： Forty patients with liver cirrhosis （LC, with or without lo...
关键词：Liver cirrhosis Hepatic encephalopathy Neuropsychiatric symptoms Clinical neuro-psychiatric rating BRADYKINESIA 
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