Epalrestat improves motor symptoms by reducing oxidative stress and inflammation in the reserpine induced mouse model of Parkinson’s disease  

作　　者：Md.Mahbubur Rahman Rupali Rani Chakraborti Md.Abdullah Potol Ariful Haque Abir Ozayra Sharmin Mahabub Alam Md.Fazlur Rahman Khan Rownock Afrin Humayra Jannat Rasiqh Wadud Zaki Farhad Habib 

机构地区：[1]Laboratory of Pharmacology,Department of Pharmaceutical Sciences,School of Health&Life Sciences,North South University,Dhaka,Bangladesh

出　　处：《Animal Models and Experimental Medicine》2020年第1期9-21,共13页动物模型与实验医学（英文）

基　　金：We thank Ms Fahmida Zaman for her initial intellectual support for this project;We are grateful to Ms Noshin Noorjahan for her editorial support for our manuscript.Department of Pharmaceutical Sciences at North South University provided the Laboratory space,including the equipment and basic reagents necessary to conduct this project.

摘　　要：Background:Parkinson's disease(PD)is a progressive neurodegenerative disorder affecting a large number of elderly people worldwide.The current therapies for PD are symptom-based;they do not provide a cure but improve the quality of life.Muscular dysfunction is the hallmark clinical feature of PD and oxidative stress and inflammation play a critical role in its pathogenesis.Epalrestat is used for the treatment of diabetic neuropathy and is known to improve antioxidative defense mechanisms in the CNS.Therefore,in this study,we investigated the role of Epalrestat in the reserpine induced mouse model of PD.Method:We used Swiss Albino mice for the PD model and tested for akinesia/bradykinesia,muscular rigidity,palpebral ptosis,and tremor,as well as conducting swim and open field tests.Brain samples were used to determine oxidative stress parameters and infiltration of immune cells.Results:Epalrestat treatment significantly improved akinesia and bradykinesia,muscular dysfunctions,tremor level,and gait functions compared to the reserpine group.It also improved the latency in the swim test.Eplarestat significantly reduced lipid peroxidation and NO concentration in different brain tissues and increased the activity of antioxidative enzymes,glutathione,catalase,and superoxide dismutase.Furthermore,Epalrestat reduced neuroinflammation by reducing the number of infiltrating immune cells.Conclusion:Eplarestat improves muscular dysfunction in PD by reducing oxidative stress and inflammation.

关 键 词：BRADYKINESIA EPALRESTAT GLUTATHIONE OXIDATIVE-STRESS Parkinson's disease 

分 类 号：R965[医药卫生—药理学] R-332[医药卫生—药学]