云南高校图书馆联盟文献共享服务平台- EPALRESTAT

EPALRESTAT: 作品数：16被引量：92H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：华正茂屠惠萍王隽杨琍苹将咏文更多>>; 相关机构：华东师范大学更多>>; 相关期刊：《Journal of Diabetes Mellitus》《Acta Pharmacologica Sinica》《Pharmacology & Pharmacy》《Journal of Beijing Institute of Technology》更多>>; 相关基金：国家自然科学基金中国博士后科学基金更多>>

Epalrestat Enhances MTS Reduction Activity Independent of Cell Numbers in Bovine Aortic Endothelial Cells: 《Pharmacology & Pharmacy》2023年第3期59-71,共13页Keisuke Sato Shoya Endo Natsuki Ota Akira Takaguri Kumi Satoh Ryosuke Tatsunami; The 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay is used as a major method to evaluate cell viability. However, in some cases, the results may reflect mitochondr...; 关键词：EPS MTS NRF2 MITOCHONDRIA BAECs

AKR1B1 promotes pancreatic cancer metastasis by regulating lysosome-guided exosome secretion: 《Nano Research》2022年第6期5279-5294,共16页Jie Ji Dandan Jin Minxue Xu Yujie Jiao Yue Wu Tong Wu Renjie Lin Wenjie Zheng Zhaoxiu Liu Feng Jiang Yihui Fan Mingbing Xiao; supported by grants from the National Natural Science Foundation(No.81702419);the National Science Fund for Distinguished Young Scholars(No.82000497);the Key Research and Development Plan of Jiangsu Province(Nos.BE2019692 and BE2020668);the Natural Science Foundation of Jiangsu Province(Nos.BK20211105 and BK20200965);the Postdoctoral Science Foundation of China(No.2019M661909);the Social Development Foundation of Nantong City(Nos.MS22020005 and MSZ20076);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Nos.KYCX20_2681,KYCX20_2673,and KYCX21_3112).; Pancreatic cancer is one of the most lethal neoplasms with high metastatic potential and is resistant to almost all current therapies.Epalrestat is an aldo-keto reductase family 1 member B1(AKR1B1)inhibitor for the tr...; 关键词：aldo-keto reductase family 1 member B1(AKR1B1) pancreatic cancer exosome secretion LYSOSOME EPALRESTAT

Effect of Epalrestat combined with Huoxue Huayu preparation on early diabetic retinopathy and its effect on serum oxidative stress and inflammatory factors: 《Journal of Hainan Medical University》2021年第3期27-30,共4页Ru Ouyang Xiang Pei Zong-Bao Li Li Zhang Hui Liu; 2019 Hainan Province Medical and Health Research Project(No.1901320244S2007)。; Objective:To investigate the effect of Epalrestat combined with Huoxue Huayu preparation on early diabetic retinopathy and its effect on serum oxidative stress and inflammatory factors.Methods:132 patients with early ...; 关键词：Early diabetic retinopathy EPALRESTAT Blood circulation and blood stasis PREPARATION Therapeutic effect Oxidative stress Inflammatory factors

Epalrestat improves motor symptoms by reducing oxidative stress and inflammation in the reserpine induced mouse model of Parkinson’s disease被引量：6: 《Animal Models and Experimental Medicine》2020年第1期9-21,共13页Md.Mahbubur Rahman Rupali Rani Chakraborti Md.Abdullah Potol Ariful Haque Abir Ozayra Sharmin Mahabub Alam Md.Fazlur Rahman Khan Rownock Afrin Humayra Jannat Rasiqh Wadud Zaki Farhad Habib; We thank Ms Fahmida Zaman for her initial intellectual support for this project;We are grateful to Ms Noshin Noorjahan for her editorial support for our manuscript.Department of Pharmaceutical Sciences at North South University provided the Laboratory space,including the equipment and basic reagents necessary to conduct this project.; Background:Parkinson's disease(PD)is a progressive neurodegenerative disorder affecting a large number of elderly people worldwide.The current therapies for PD are symptom-based;they do not provide a cure but improve ...; 关键词：BRADYKINESIA EPALRESTAT GLUTATHIONE OXIDATIVE-STRESS Parkinson's disease

Study on degradation kinetics of epalrestat in aqueous solutions and characterization of its major degradation products under stress degradation conditions by UHPLC-PDA-MS/MS被引量：2: 《Journal of Pharmaceutical Analysis》2019年第6期423-430,共8页Hong Sun Suyan Liu Xun Gao Zhili Xiong Zhonggui He Longshan Zhao; Drug stability is closely related to drug safety and needs to be considered in the process of drug production,package and storage.To investigate the stability of epalrestat,a carboxylic acid derivative,a reversed-phas...; 关键词：EPALRESTAT RP-HPLC Degradation kinetics UHPLC-PDA-MS/MS Degradation products

The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation被引量：16: 《Acta Pharmacologica Sinica》2019年第1期86-97,共12页Jun He Hao-xue Gao Na Yang Xiao-dong Zhu Run-bin Sun Yuan Xie Cai-hong Zeng Jing-wei Zhang Jian-kun Wang Fei Ding Ji-ye Aa Guang-ji Wang; the National Natural Science Foundation of the People's Republic of China (81530098);the National Key Special Project of Science and Technology for Innovation Drugs of China (2017ZX09301013,2015ZX09501001);the Natural Science Foundation of Jiangsu Province (BL2014070);the project of university collaborative innovation center of Jiangsu province (Modern Chinese Medicine Center and Biological Medicine Center).; Epalrestat is an inhibitor of aldose reductase in the polyol pathway and is used for the management of diabetic neuropathy clinically.Our pilot experiments and accumulated evidences showed that epalrestat inhibited po...; 关键词：diabetes DIABETIC NEPHROPATHY POLYOL pathway metabolomics ALDOSE REDUCTASE

Efficacy of epalrestat plus α-lipoic acid combination therapy versus monotherapy in patients with diabetic peripheral neuropathy: a meta-analysis of 20 randomized controlled trials被引量：20: 《Neural Regeneration Research》2018年第6期1087-1095,共9页Ming Zhao Jia-Yi Chen Yu-Dong Chu Ya-Bin Zhu Lin Luo Shi-Zhong Bu; supported by the National Natural Science Foundation of China,No.81370165;a grant from the Public Benefit Technology and Society Development Program of Zhejiang Province of China,No.2015C33309;a grant from the Ningbo Science and Technology Innovation Team Program in China,No.2014B82002,2015B11050;a grant from the Ningbo Science and Technology Project in China,No.2015A610217;the Fang Runhua Fund of Hong Kong,K.C.Wong Magna Fund in Ningbo University; OBJECTIVE： To evaluate the efficacy of α-lipoic acid（ALA） plus epalrestat combination therapy in the treatment of diabetic peripheral neuropathy（DPN）. DATA SOURCES： The electronic databases of Pub Med, Medline,...; 关键词：nerve regeneration ANTIOXIDANT aldose reductase inhibitor diabetic complication DIABETES combination therapy nerve conduction velocity nerve electrophysiology peripheral nerve injury neural regeneration

Assessment of the renal function, peroxidation damage and inflammatory injury after epalrestat combined with alprostadil treatment of early diabetic nephropathy: 《Journal of Hainan Medical University》2017年第5期29-32,共4页Hai-Xia Li Shu-Juan Liu; Objective:To study the renal function, peroxidation damage and inflammatory injury after epalrestat combined with alprostadil treatment of early diabetic nephropathy.Methods:90 patients with early diabetic nephropathy...; 关键词：Early DIABETIC NEPHROPATHY EPALRESTAT ALPROSTADIL Renal function PEROXIDATION DAMAGE

浙江大学科学家揭示糖尿病药物Epalrestat或可治疗基底样型乳腺癌: 《海南医学》2017年第6期F0003-F0003,共1页王丽; 基底样型乳腺癌（basal-like breast cancer）是乳腺癌中最为凶险的一个亚型,其治疗长期未能取得突破。近期,浙江大学医学院肿瘤研究中心董辰方教授团队揭示：基底样乳腺癌细胞中一种名为AKR1B1的酶能为癌细胞＂松绑＂,为其扩散转移铺...; 关键词：浙江大学医学院乳腺癌细胞糖尿病药物基底样治疗科学家癌细胞转移糖尿病并发症

Evaluation of renal function and oxidative stress after adjuvant epalrestat treatment of early diabetic nephropathy: 《Journal of Hainan Medical University》2017年第4期69-73,共5页Ge Zhao Min-Xiu Yao; Objective:To explore the influence of adjuvant epalrestat treatment of early diabetic nephropathy on renal function and oxidative stress.Methods:A total of 80 patients with early diabetic nephropathy who were treated ...; 关键词：Early DIABETIC NEPHROPATHY EPALRESTAT RENAL function OXIDATIVE stress

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