Cushing's syndrome caused by giant Ewing's sarcoma of the kidney:A case report and review of literature  

作　　者：Guo-Fan Dong Ya-Kun Hou Qi Ma Shuang-Yu Ma Yu-Jie Wang Mulati Rexiati Wen-Guang Wang 

机构地区：[1]Department of Urologic Surgery,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang Uygur Autonomous Region,China

出　　处：《World Journal of Clinical Cases》2024年第23期5431-5440,共10页世界临床病例杂志

基　　金：invaluable support and useful discussions with other members of the urology department.

摘　　要：BACKGROUND Primary renal Ewing’s sarcoma(ES)is extremely rare,and only two cases causing Cushing’s syndrome(CS)have been reported to date.We report that the case of an 18-year-old patient is diagnosed primary renal ES with typical CS characterized by purple stripes,weight gain,and hypertension.CASE SUMMARY CS was first diagnosed by laboratory testing.A huge tumor was revealed in the kidney following an imaging examination.Moreover,brain and bone metastases were observed.After comprehensive treatment,primarily based on surgery,primary renal ES was pathologically diagnosed with a typical EWSR1-FLI1 genetic mutation through genetic testing.Furthermore,the glucocorticoid level returned to normal.By the ninth postoperative month of follow-up,the patient was recovering well.Cushing-related symptoms had improved,and a satisfactory curative effect was achieved.CONCLUSION Primary renal ES,a rare adult malignant tumor,can cause CS and a poor prognosis.

关 键 词：RENAL KIDNEY Ewing's sarcoma Neuroectodermal tumors Cushing syndrome Case report 

分 类 号：R572.3[医药卫生—消化系统] R749.4[医药卫生—内科学]