What enlightenment has the development of lung cancer bone metastasis brought in the last 22 years  

作　　者：Yi Chen Xiao-Song Chen Rong-Quan He Zhi-Guang Huang Hui-Ping Lu Hong Huang Da-Ping Yang Zhong-Qing Tang Xia Yang Han-Jie Zhang Ning Qv Jin-Liang Kong Gang Chen 

机构地区：[1]Department of Pathology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China [2]Department of Medical Oncology,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China [3]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China [4]Department of Pathology,Guigang People’s Hospital of Guangxi/The Eighth Affiliated Hospital of Guangxi Medical University,Guigang 537100,Guangxi Zhuang Autonomous Region,China [5]Department of Pathology,Wuzhou Gongren Hospital/The Seventh Affiliated Hospital of Guangxi Medical University,Wuzhou 543000,Guangxi Zhuang Autonomous Region,China

出　　处：《World Journal of Clinical Oncology》2024年第6期765-782,共18页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Lung cancer bone metastasis(LCBM)is a disease with a poor prognosis,high risk and large patient population.Although considerable scientific output has accumulated on LCBM,problems have emerged,such as confusing research structures.AIM To organize the research frontiers and body of knowledge of the studies on LCBM from the last 22 years according to their basic research and translation,clinical treatment,and clinical diagnosis to provide a reference for the development of new LCBM clinical and basic research.METHODS We used tools,including R,VOSviewer and CiteSpace software,to measure and visualize the keywords and other metrics of 1903 articles from the Web of Science Core Collection.We also performed enrichment and proteinprotein interaction analyses of gene expression datasets from LCBM cases worldwide.RESULTS Research on LCBM has received extensive attention from scholars worldwide over the last 20 years.Targeted therapies and immunotherapies have evolved into the mainstream basic and clinical research directions.The basic aspects of drug resistance mechanisms and parathyroid hormone-related protein may provide new ideas for mechanistic study and improvements in LCBM prognosis.The produced molecular map showed that ribosomes and focal adhesion are possible pathways that promote LCBM occurrence.CONCLUSION Novel therapies for LCBM face animal testing and drug resistance issues.Future focus should centre on advancing clinical therapies and researching drug resistance mechanisms and ribosome-related pathways.

关 键 词：Lung cancer Bone metastasis BIBLIOMETRICS Targeted therapy IMMUNOTHERAPY Enrichment analysis 

分 类 号：R73-37[医药卫生—肿瘤]