Novel insights into autophagy in gastrointestinal pathologies,mechanisms in metabolic dysfunction-associated fatty liver disease and acute liver failure  

作　　者：Tsvetelina Velikova Milena Gulinac 

机构地区：[1]Medical Faculty,Sofia University St Kliment Ohridski,Sofia 1407,Bulgaria [2]Department of General and Clinical Pathology,Medical University of Plovdiv,Plovdiv 4002,Bulgaria

出　　处：《World Journal of Gastroenterology》2024年第27期3273-3277,共5页世界胃肠病学杂志（英文版）

基　　金：Supported by the European Union-NextGenerationEU,through The National Recovery and Resilience Plan of The Republic of Bulgaria,No.BG-RRP-2.004-0008。

摘　　要：In this editorial,we comment on three articles published in a recent issue of World Journal of Gastroenterology.There is a pressing need for new research on autophagy's role in gastrointestinal(GI)disorders,and also novel insights into some liver conditions,such as metabolic dysfunction-associated fatty liver disease(MAFLD)and acute liver failure(ALF).Despite advancements,understanding autophagy's intricate mechanisms and implications in these diseases remains incomplete.Moreover,MAFLD's pathogenesis,encompassing hepatic steatosis and metabolic dysregulation,require further elucidation.Similarly,the mechanisms underlying ALF,a severe hepatic dysfunction,are poorly understood.Innovative studies exploring the interplay between autophagy and GI disorders,as well as defined mechanisms of MAFLD and ALF,are crucial for identifying therapeutic targets and enhancing diagnostic and treatment strategies to mitigate the global burden of these diseases.

关 键 词：Gastrointestinal diseases AUTOPHAGY Metabolic dysfunction-associated fatty liver disease High-normal alanine aminotransferase level Silent information regulator sirtuin 1 Acute liver failure 

分 类 号：R575[医药卫生—消化系统]