Involvement of haptoglobin in disease development  

作　　者：Romaric Tuono De Manfouo JosuéSimo Louokdom Bernard Claude Chetcha Larissa Michelle BakamMagoua Prosper Cabral Biapa Nya Constant Anatole Pieme Claude Tayou Tagny 

机构地区：[1]Department of Microbiology,Parasitology,Hematology,and Infectious Diseases,Hematology Unit,Faculty of Medicine and Biomedical Sciences,University of Yaoundé1,Yaoundé296,Cameroon [2]Higher Institute of Health Sciences,Universitédes Montagnes,Bangangté296,Cameroon [3]Public Health and Biotechnology Research Laboratory(LAPHER-Biotech),Faculty of Sciences,University of Yaoundé1,Yaoundé296,Cameroon [4]Faculty of Sciences,Universitéde Dschang,Dschang 296,Cameroon [5]Department of Biochemistry,Faculty of Medicine and Biomedical Sciences,University of Yaoundé1,Yaoundé296,Cameroon

出　　处：《World Journal of Hematology》2024年第2期1-7,共7页世界血液学杂志

摘　　要：Haptoglobin(HP)is a liver glycoprotein that is actively synthesized during in-flammatory and hemolytic processes.It also has pro-oxidant and proinflam-matory properties,which are a function of its genotype.The genetic polymorp-hism of the chains leads to synthesis of three phenotypes/proteins,which are related to the number and type of chains and their molecular weight,namely HP1-1,HP1-2 and HP2-2.Patients with HP2-2 have more vascular complications,while those with HP1-1 have fewer.HP is involved in the worsening of diseases,such as HP2-2 in aggravation of vaso-occlusive crises in sickle cell disease,and worsening of the pathophysiology of other diseases.In contrast,HP1-1 confers better protection against diseases.All of this suggests that further studies should be conducted,including experimental and analytical studies focused on de-monstrating the influence of different HP genotypes on individual clinical and hematological data.This would help in understanding the role played by this genetic polymorphism in the pathophysiology of diseases.

关 键 词：HAPTOGLOBIN PROTEIN PROPERTIES POLYMORPHISM DISEASES 

分 类 号：O62[理学—有机化学]