Correlation between postoperative chemotherapy regimen and survival in patients with resectable gastric adenocarcinoma accompanied with vascular cancer thrombus  

作　　者：Ze-Feng Yang Zhuan-Xia Dong Chen-Jie Dai Li-Zheng Fu Hong-Mei Yu Yu-Sheng Wang 

机构地区：[1]Department of Health Statistics,School of Public Health,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China [2]Shanxi Medical University,Taiyuan 030001,Shanxi Province,China [3]Shanxi Provincial Key Laboratory of Major Diseases Risk Assessment,Taiyuan 030001,Shanxi Province,China [4]MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China [5]Department of Oncology Digestive,The First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China [6]Department of Digestive Oncology,Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital,Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University,Taiyuan 030001,Shanxi Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第6期1618-1628,共11页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by Shanxi Provincial Health Commission,No.20222025;Four“Batches”Innovation Project of Invigorating Medical Cause through Science and Technology of Shanxi Province,No.2023XM024.

摘　　要：BACKGROUND Patients with resectable gastric adenocarcinoma accompanied by vascular cancer thrombus(RGAVCT)have a poor prognosis,with a 5-year survival rate ranging from 18.42%-53.57%.These patients need a reasonable postoperative treatment plan to improve their prognosis.AIM To determine the most effective postoperative chemotherapy regimen for patients with RGAVCT.METHODS We retrospectively collected the clinicopathological data of 530 patients who un-derwent radical resection for gastric cancer between January 2017 and January 2022 and who were pathologically diagnosed with gastric adenocarcinoma with a choroidal cancer embolus.Fur-thermore,we identified the high-risk variables that can influence the prognosis of patients with RGAVCT by asse-ssing the clinical and pathological features of the patients who met the inclusion criteria.We also assessed the significance of survival outcomes using Mantel-Cox univariate and multivariate analyses.The subgroups of pa-tients with stages Ⅰ,Ⅱ,and Ⅲ disease who received single-,dual-,or triple-drug regimens following surgery were analyzed using SPSS 25.0 and the ggplot2 package in R 4.3.0.RESULTS In all,530 eligible individuals with RGAVCT were enrolled in this study.The median overall survival(OS)of patients with RGAVCT was 24 months,and the survival rates were 80.2%,62.5%,and 42.3%at 12,24,and 59 months,respectively.Preoperative complications,tumor size,T stage,and postoperative chemotherapy were identified as independent factors that influenced OS in patients with RGAVCT according to the Cox multivariate analysis model.A Kaplan-Meier analysis revealed that chemotherapy had no effect on OS of patients with stage Ⅰ or Ⅱ RGAVCT;however,chemotherapy did have an effect on OS of stage Ⅲ patients.Stage Ⅲ patients who were treated with chemotherapy consisting of dual-or triple-agent regimens had better survival than those treated with single-agent regimens,and no significant difference was observed in the survival of patients treated with chemo-therapy consisting o

关 键 词：Vascular cancer embolism Postoperative chemotherapy regimen Gastric adenocarcinoma Risk factors SURVIVAL 

分 类 号：R735.2[医药卫生—肿瘤]