Insulin resistance as the molecular link between diabetes and Alzheimer's disease  

作　　者：Mona Mohamed Ibrahim Abdalla 

机构地区：[1]Department of Human Biology,School of Medicine,International Medical University,Bukit Jalil 57000,Kuala Lumpur,Malaysia

出　　处：《World Journal of Diabetes》2024年第7期1430-1447,共18页世界糖尿病杂志（英文版）（电子版）

摘　　要：Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence worldwide.Recent studies have indicated a possible link between DM and an increased risk of developing AD.Insulin,while primarily known for its role in regulating blood sugar,also plays a vital role in protecting brain functions.Insulin resistance(IR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's development.When insulin signalling becomes dysfunctional,it can negatively affect various brain functions,making individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein tangles.Emerging research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to AD.This review aims to explore the relationship between DM and AD,with a focus on the role of IR.It also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target IR.Understanding IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关 键 词：Alzheimer's disease Insulin resistance OBESITY DEMENTIA DIABETES Metabolic syndrome 

分 类 号：R587.1[医药卫生—内分泌] R749.16[医药卫生—内科学]