Drug delivery with Mn-doped MoO_(2) for photothermalenhanced chemotherapy in fighting cancers  

作　　者：Ping Zhao Hai-Fa Zheng Ju Peng Xing-Long Li Fazal Raziq Xiao-Jun Liu Hao-Quan Yu Jin-Lu Tang Yi-Fan Kang Wen-Huan Huang 

机构地区：[1]School of Chemistry and Chemical Engineering,Guangdong Pharmaceutical University,Guangzhou 510006,China [2]KAUST Catalysis Center,King Abdullah University of Science and Technology,23955-6900 Thuwal,Kingdom of Saudi Arabia [3]Key Laboratory of Chemical Additives for China National Light Industry,College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology,Xi'an 710021,China

出　　处：《Rare Metals》2024年第5期2230-2240,共11页稀有金属（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.22271178 and 22001156);Project of Special Key Fields in Guangdong Province(No.2021ZDZX4019);the Science and technology innovation strategy of Guangdong province(No.51361212);Guangdong Provincial Science and Technology Innovation Strategy Special Fund Approval Project(No.pdjh2021b0266)。

摘　　要：Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant concerns.Nanoplatforms used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing properties.Herein,Mn-doped MoO_(2)nanoparticles coated with ZrO_(2)and capped with Bi_(2)O_(3)have been designed as a DDS,namely MMZB.MMZB possesses good magnetic properties,great photothermal conversion ability,sensitive tumor microenvironment(TME)responsiveness,and good biocompatibility in hemocompatibility in vitro.Thus,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal combined therapy.MMZB@DNM demonstrates a more impressive anti-cancer effect than the individual photothermal or chemotherapy both in vitro and in vivo.Furthermore,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in vivo.This contribution provides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.

关 键 词：Mn-doped MoO_(2) Bi_(2)O_(3) NANOCARRIER Photothermal CHEMOTHERAPY 

分 类 号：R730.53[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]