固定化脂肪酶手性拆分(R,S)-1-苯基乙醇研究进展  

Research Progress on Chiral Resolution of(R,S)-1-phenylethanol by Immobilized Lipase

作　　者：汪建华 夏胜旗 颜润悦 史笑元 王睿 彭梦杰 Wang Jianhua;Xia Shenqi;Yan Runyue;Shi Xiaoyuan;Wang Rui;Peng Mengjie(Suzhou Chien-shiung Institute of Technology,Taicang 215411,China)

机构地区：[1]苏州健雄职业技术学院,江苏太仓215411

出　　处：《广东化工》2024年第11期62-64,共3页Guangdong Chemical Industry

基　　金：江苏省自然科学基金项目(BK20220301);江苏省“双创计划”项目(JSSCBS20221009);江苏高校“青蓝工程”资助项目(苏教师函[2024]14号);太仓市基础研究计划项目(TC2022JC29,TC2022JC25)。

摘　　要：(R,S)-1-苯基乙醇是药物合成与精细化学品的重要中间体,可经固定化脂肪酶不对称催化获得光学纯1-苯基乙醇。本文分别从脂肪酶类型、溶剂工程、固定化技术三方面综述了国内外固定化脂肪酶手性拆分(R,S)-1-苯基乙醇的研究进展,并指明该领域中亟待解决的关键问题及解决思路,以期为后续固定化脂肪酶应用于手性拆分(R,S)-1-苯基乙醇提供参考。(R,S)-1-phenylethanol is an important intermediate in drug synthesis and fine chemicals,and the intermediate can be asymmetrically catalyzed by immobilized lipase to obtain optically pure 1-phenylethanol.In this paper,the latest progress from three aspects of lipase type,solvent engineering,immobilization technique about the chiral preparation of(R,S)-1-phenylethanol via immobilized lipase has been reviewed,and we point out the problems to be urgently solved and propose some ideas to solve the problems in order to provide a little inspiration and reference for the chiral resolution of(R,S)-1-phenylethanol by immobilized lipase in the future.

关 键 词：脂肪酶 手性拆分 固定化酶 (R S)-1-苯基乙醇 生物催化 

分 类 号：TQ[化学工程]