A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome  

作　　者：Xiaolei Liu Esteban Delgado 

机构地区：[1]Lemole Center for Integrated Lymphatics and Vascular Research,Lewis Katz School of Medicine at Temple University,Philadelphia,PA,19140,USA

出　　处：《Acta Pharmacologica Sinica》2024年第7期1530-1532,共3页中国药理学报（英文版）

摘　　要：The ubiquitin-proteasome system (UPS) constitutes a highly conserved protein degradation system in eukaryotic cells [1], comprising ubiquitin, ubiquitin enzymes, the 26 S proteasome, and deubiquitinating enzymes. The ubiquitin-proteasome degradation process involves a cascade reaction, in which proteins undergoing ubiquitination are ultimately degraded by the 26 S proteasome. This proteasome comprises a 20 S core subunit, 19 S regulatory subunit, and an 11 S regulatory subunit.

关 键 词：PROTEASOME ATHEROSCLEROSIS BEYOND 

分 类 号：R96[医药卫生—药理学]