The Neurovascular Unit Dysfunction in the Molecular Mechanisms of Epileptogenesis and Targeted Therapy  

作　　者：Xiuxiu Liu Ying Zhang Yanming Zhao Qian Zhang Feng Han 

机构地区：[1]Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases,Ministry of Education,Nanjing,211166,China [2]International Joint Laboratory for Drug Target of Critical Illnesses,School of Pharmacy,Nanjing Medical University,Nanjing,211166,China [3]Institute of Brain Science,The Affiliated Brain Hospital of Nanjing Medical University,Nanjing,211166,China [4]Gusu School,Nanjing Medical University,Suzhou Municipal Hospital,The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou,210019,China

出　　处：《Neuroscience Bulletin》2024年第5期621-634,共14页神经科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China(81930103);the National Natural Science Foundations of China(82104162);the Natural Science Foundation of Jiangsu Province(BK20210539).

摘　　要：Epilepsy is a multifaceted neurological syndrome characterized by recurrent,spontaneous,and synchronous seizures.The pathogenesis of epilepsy,known as epileptogenesis,involves intricate changes in neurons,neuroglia,and endothelium,leading to structural and functional disorders within neurovascular units and culminating in the development of spontaneous epilepsy.Although current research on epilepsy treatments primarily centers around anti-seizure drugs,it is imperative to seek effective interventions capable of disrupting epileptogenesis.To this end,a comprehensive exploration of the changes and the molecular mechanisms underlying epileptogenesis holds the promise of identifying vital biomarkers for accurate diagnosis and potential therapeutic targets.Emphasizing early diagnosis and timely intervention is paramount,as it stands to significantly improve patient prognosis and alleviate the socioeconomic burden.In this review,we highlight the changes and molecular mechanisms of the neurovascular unit in epileptogenesis and provide a theoretical basis for identifying biomarkers and drug targets.

关 键 词：EPILEPTOGENESIS Neurovascular unit Molecular mechanisms Drug targets 

分 类 号：R749.16[医药卫生—神经病学与精神病学]