mTORC2:The“Ace in the Hole”for a Broader Control of Epileptic Seizures?  

作　　者：Shuo Zhang Xiongfeng Guo Wei Huang Cenglin Xu 

机构地区：[1]Department of Pharmacy,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine),Hangzhou,310006,China [2]The Second Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Xinhua Hospital),Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou,310053,China

出　　处：《Neuroscience Bulletin》2024年第5期677-679,共3页神经科学通报（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(82173796 and 82374064);the Medical and Health Research Project of Zhejiang Province,China(2021RC097).

摘　　要：Over 70 million people worldwide suffer from epilepsy-one of the most prevalent chronic neurological disorders[1].Despite the availability of over thirty anti-seizure drugs(ASDs)that mainly act on voltage-gated ion channels or inhibitory GABAergic receptors,the effectiveness of these drugs in achieving seizure freedom remains unsatisfactory due to pharmacoresistance and the inevitable occurrence of side-effects.

关 键 词：DRUGS SPITE EPILEPSY 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术] R742.1[自动化与计算机技术—计算机科学与技术]