Superparamagnetic iron oxide nanoparticle regulates microbiota–gut–inner ear axis for hearing protection  

作　　者：Zhanhang Guo Yunhao Wu Bo Chen Mengdie Kong Peng Xie Yan Li Dongfang Liu Renjie Chai Ning Gu 

机构地区：[1]Jiangsu Key Laboratory for Biomaterials and Devices,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210009,China [2]Medical Science and Technology Innovation Center,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250000,China [3]State Key Laboratory of Digital Medical Engineering,Department of Otolaryngology Head and Neck Surgery,Zhongda Hospital,School of Life Sciences and Technology,School of Medicine,Advanced Institute for Life and Health,Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research,Southeast University,Nanjing 210096,China [4]Institute of Materials Science and Devices,School of Materials Science and Engineering,Suzhou University of Science and Technology,Suzhou 215009,China [5]Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging&Interventional Radiology&Vascular Surgery,Department of Radiology,Medical School,Zhongda Hospital,Southeast University,Nanjing 210009,China [6]Co-Innovation Center of Neuroregeneration,Nantong University,Nantong 226001,China [7]School of Medical Technology,Institute of Engineering Medicine,Beijing Institute of Technology,Beijing 100081,China [8]Department of Otolaryngology Head and Neck Surgery,Sichuan Provincial People’s Hospital,University of Electronic Science and Technology of China,Chengdu 610072,China [9]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [10]Southeast university Shenzhen research institute,Shenzhen 518063,China [11]Cardiovascular Disease Research Center,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Medical School,Nanjing University,Nanjing 210093,China

出　　处：《National Science Review》2024年第6期266-277,共12页国家科学评论（英文版）

摘　　要：Noise-induced hearing loss (NIHL) is a highly prevalent form of sensorineural hearing damage that hassignificant negative effects on individuals of all ages and there are no effective drugs approved by the USFood and Drug Administration. In this study, we unveil the potential of superparamagnetic iron oxidenanoparticle assembly (SPIOCA) to reshape the dysbiosis of gut microbiota for treating NIHL. Thismodulation inhibits intestinal inflammation and oxidative stress responses, protecting the integrity of theintestinal barrier. Consequently, it reduces the transportation of pathogens and inflammatory factors fromthe bloodstream to the cochlea. Additionally, gut microbiota-modulated SPIOCA-induced metabolicreprogramming in the gut–inner ear axis mainly depends on the regulation of the sphingolipid metabolicpathway, which further contributes to the restoration of hearing function. Our study confirms the role of themicrobiota–gut–inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL andother microbiota dysbiosis-related diseases.

关 键 词：superparamagnetic iron oxide nanoparticle hearing loss gut microbiota INFLAMMATION sphingolipid metabolism microbiota-gut-inner ear axis 

分 类 号：R730.5[医药卫生—肿瘤]