食品添加剂安全评估技术及其应用  

Food Additive Safety Assessment Technology and Its Application

作　　者：陆丹丹 LU Dandan(Jiangsu College of Tourism,Yangzhou 225100,China)

机构地区：[1]江苏旅游职业学院,江苏扬州225100

出　　处：《食品安全导刊》2024年第14期176-178,182,共4页China Food Safety Magazine

摘　　要：本文系统梳理了食品添加剂安全性评估的各项关键技术,包括毒理学评估方法如毒代动力学、毒效动力学和基于组学的机制研究,风险评估策略如定量结构-活性关系(Quantitative Structure Activity Relationship,QSAR)模型、基准剂量法和敏感人群与累积风险评估,以及新兴评估技术如高通量毒性筛选、人源化动物模型和生理毒代动力学建模等。新兴技术和策略的应用,将极大拓展食品安全风险评估的科学内涵,为保障膳食安全和人们的健康提供更有力的技术支撑。This paper systematically combs the key technologies for safety assessment of food additives,including toxicological assessment methods such as toxicodynamics,toxicence dynamics and omics-based mechanism research,risk assessment strategies such as quantitative structure-activity relationship(QSAR)model,benchmark dosing method and sensitive population and cumulative risk assessment,and emerging assessment technologies such as high-throughput toxicity screening,humanized animal model and physiological toxickinetic modeling.The application of emerging technologies and strategies will greatly expand the scientific connotation of food safety risk assessment,and provide stronger technical support for ensuring dietary safety and human health.

关 键 词：添加剂 安全评估 食品质量监测 

分 类 号：TS202.3[轻工技术与工程—食品科学] TS201.6[轻工技术与工程—食品科学与工程]