低频重复经颅磁刺激治疗青少年难治性抑郁症的效果观察  

Observation on the Effect of Low-frequency Repetitive Transcranial Magnetic Stimulation in the Treatment of Refractory Depression in Adolescents

作　　者：晏克文 李学艺 范月圆 吴朴聪 Yan Kewen;Li Xueyi;Fan Yueyuan;Wu Pucong(Department of Psychiatry,the Third People's Hospital of Qujing City,Qujing 655000,Yunnan Province,China;Department of Psychiatry Second Ward,the Third People's Hospital of Qujing City,Qujing 655000,Yunnan Province,China;Children and Youth Mental Health Service Center of the Third People's Hospital of Qujing City,Qujing 655000,Yunnan Province,China)

机构地区：[1]曲靖市第三人民医院精神科,云南曲靖655000 [2]曲靖市第三人民医院精神科二病区,云南曲靖655000 [3]曲靖市第三人民医院儿童青少年心理健康服务中心,云南曲靖655000

出　　处：《中外医药研究》2024年第16期57-59,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察低频重复经颅磁刺激(rTMS)治疗青少年难治性抑郁症(TRD)的效果。方法:选取2021年4月—2023年4月曲靖市第三人民医院精神科收治的青少年TRD患者92例作为研究对象,随机分为观察组与对照组,各46例。两组均接受盐酸舍曲林治疗,观察组在盐酸舍曲林基础上接受低频rTMS治疗,对照组在盐酸舍曲林基础上接受改良电休克疗法治疗。比较两组患者临床疗效、认知与执行功能、持续性注意力、不良事件发生情况。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.001)。治疗后,两组总反应数、持续性错误数、非持续性错误数比较,差异无统计学意义(P>0.05);观察组正确反应数、完成分类数高于治疗前及对照组,差异有统计学意义(P<0.05)。治疗前及治疗后,两组持续操作测验结果比较,差异无统计学意义(P>0.05)。结论:低频rTMS治疗青少年TRD效果显著,可改善患者执行功能,且不影响患者的认知功能及注意力。Objective:To observe the effect of low-frequency repetitive transcranial magnetic stimulation(rTMS)in the treatment of adolescent refractory depression(TRD).Methods:Ninety-two adolescent TRD patients admitted to the Department of Psychiatry of the Third People's Hospital of Qujing City from April 2021 to April 2023 were selected as the study subjects,and were randomly divided into the observation group and the control group,with forty-six cases in each group.Both groups were treated with sertraline hydrochloride,and the observation group was treated with low-frequency rTMS on the basis of sertraline hydrochloride,while the control group was treated with modified electroconvulsive therapy on the basis of sertraline hydrochloride.The clinical efficacy,cognitive and executive functions,sustained attention,and adverse events were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.001).After the treatment,the number of total responses,the number of persistent errors,and the number of non-persistent errors in the two groups were compared,and the differences were not statistically significant(P>0.05);the number of correct responses and the number of completed classifications in the observation group were higher than that in the pre-treatment and control groups,and the differences were statistically significant(P<0.05).Comparison of the results of continuous operation test between the two groups before and after treatment,the difference was not statistically significant(P>0.05).Conclusion:Low-frequency rTMS is effective in the treatment of adolescent TRD,which can improve the executive function of patients and does not affect their cognitive function and attention.

关 键 词：低频重复经颅磁刺激 青少年 难治性抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]