Gedunin attenuates streptozotocin-induced diabetic hepatopathy in rats  

作　　者：Suchismita Mazumdar Thankamani M Marar Jyoti M Patki 

机构地区：[1]School of Biotechnology and Bioinformatics,D.Y.Patil Deemed to be University,Navi Mumbai 400614,India

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2024年第7期288-297,共10页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To examine the hepatoprotective effects of gedunin in streptozotocin(STZ)-induced diabetic rats.Methods:Rats were divided into 4 groups:control,STZ,gedunin,and STZ+gedunin.Biochemical parameters for liver function and liver histology were studied.The molecular interaction of gedunin with the liver glucose transporters GLUT2 and SGLT1 was examined using AutoDock Vina.Results:Gedunin attenuated STZ-induced increase in the levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,lactate dehydrogenase and gamma-glutamyl transferase in the serum and liver tissue,reduced lipid peroxidation,and enhanced antioxidant activity.Histopathological studies showed considerable restoration of liver architecture in gedunin-treated diabetic rats.In silico studies revealed stable binding of gedunin with GLUT2 and SGLT1.Conclusions:Gedunin exerts hepatoprotective effects in STZ-induced diabetic rats by reducing liver enzymatic activities and oxidative stress.Further studies are warranted to verify the mechanism of its hepatoprotective action.

关 键 词：Gedunin GLUT2 SGLT1 Diabetic hepatopathy DOCKING HISTOLOGY Homology modelling 

分 类 号：R575[医药卫生—消化系统] R587.1[医药卫生—内科学] R28[医药卫生—临床医学]