Skeletal interoception in osteoarthritis  

作　　者：Dinglong Yang Jiawen Xu Ke Xu Peng Xu 

机构地区：[1]Department of Joint Surgery,Honghui Hospital,Xi’an Jiaotong University,Xi’an 710054,China [2]Department of Orthopedic Surgery and Orthopedic Research Institute,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Bone Research》2024年第2期241-254,共14页骨研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(82072432).

摘　　要：The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism.Among its various forms,skeletal interoception specifically regulates the metabolic homeostasis of bones.Osteoarthritis(OA)is a complex joint disorder involving cartilage,subchondral bone,and synovium.The subchondral bone undergoes continuous remodeling to adapt to dynamic joint loads.Recent findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone,resulting in subchondral bone sclerosis in OA.The skeletal interoception is also a potential mechanism for chronic synovial inflammation in OA.In this review,we offer a general overview of interoception,specifically skeletal interoception,subchondral bone microenviroment and the aberrant subchondral remedeling.We also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA,as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

关 键 词：HOMEOSTASIS INFLAMMATION RELEASING 

分 类 号：R684.3[医药卫生—骨科学]