Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis  

作　　者：Dan Mo Zhong-Hong Zeng Xin Sui Rong Li Yi-Hua Yang 

机构地区：[1]Guangxi Reproductive Medical Center,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China [2]Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases,Nanning 530021,China [3]Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,Nanning 530021,China [4]Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing 100191,China [5]Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital),Beijing 100191,China

出　　处：《Reproductive and Developmental Medicine》2024年第2期111-120,共10页生殖与发育医学（英文版）

基　　金：financially supported by grants to Y.H.Y.from the Natural Science Foundation of Guangxi Zhuang Autonomous Region(2019GXNSFFA245013,2018GXNSFDA050017);the National Natural Science Foundation of China(81871172);the Guangxi Medical University Training Program for Distinguished Young Scholars.This review was also supported by Special Fund of the Female Fertility Preservation Innovation Team of the First Affiliated Hospital of Guangxi Medical University.

摘　　要：The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be crucial.According to previous studies,folliculogenesis is an energy-demanding process.In fact,well-balanced follicular energy metabolism is associated with ovarian function and female fertility.Consequently,glucose metabolism has been widely described as the main source of energy during folliculogenesis.Generally,the follicular glucose metabolism profiles change dynamically during follicular development.Metabolic abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in females.The signaling pathways in follicles appear to form a link between glucose metabolism and folliculogenesis.Therefore,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental competence.This review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关 键 词：FOLLICULOGENESIS Glucose metabolism GLYCOLYSIS Oxidative phosphorylation Signaling pathway 

分 类 号：R339.22[医药卫生—人体生理学]