Microenvironment responsive pod-structured astaxanthin nanocarrier for ameliorating inflammatory bowel disease  

作　　者：Jingting Wang Yuanyuan Chen Linlin Han Shasha Xia Xingyao Zhang Peng Xue Yuejun Kang Jian Ming Zhigang Xu 

机构地区：[1]Key Laboratory of Luminescence Analysis and Molecular Sensing,Ministry of Education,School of Materials and Energy&Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices,Southwest University,Chongqing 400715,China [2]College of Food Science,Southwest University,Chongqing 400715,China [3]State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University,Changsha 410082,China

出　　处：《Chinese Chemical Letters》2024年第7期360-366,共7页中国化学快报（英文版）

基　　金：financially supported by the Chongqing Graduate Program of Research and Innovation(No.CYS22207);the National Natural Science Foundation of China(No.51703187);Chongqing Talents of Exceptional Young Talents Project,China(Nos.CQYC202005029 and cstc2021ycjh-bgzxm0061)。

摘　　要：Anti-inflammatory drugs targeting inflammatory bowel disease(IBD)have attracted considerable attention but still face low therapeutic outcomes and frequent side effects.Astaxanthin(ATX),a natural ketone,possesses potent antioxidant and anti-inflammatory properties.However,it faces problems such as poor water solubility,photothermal instability,and low bioavailability.Here,we employed a supramolecular encapsulation strategy to create a nanoscale oral delivery system for ATX(referred to as FC-ATX NPs)by coupling fucoidan(FUC)with chitosan oligosaccharides(COS).The obtained FC-ATX NPs exhibited a particular“bean pod”structure with uniform size,good encapsulation efficiency,excellent physical and chemical stability,pH-triggered intestinal targeted slow-release properties,and potent antioxidant capacity.In vitro cell culture experiments showed that FC-ATX NPs promoted cellular uptake and scavenged excessive intracellular reactive oxygen species(ROS).In mouse models of colitis,FC-ATX NPs enhanced the drug absorption of intestinal epithelial cells and effectively accumulated at the site of inflammation.This work provides an efficient approach to enhance the bioavailability of ATX and has excellent application potential as an oral targeted delivery system for colitis therapy.

关 键 词：Oral administration ASTAXANTHIN NANOCARRIER Anti-oxidant activity Colon targeting 

分 类 号：R574[医药卫生—消化系统] TB383.1[医药卫生—内科学]