The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats  

作　　者：Wenhao Zheng Xiaofeng Lu Guangjin Chen Yufeng Shen Xiaofei Huang Jinfeng Peng Jiajia Wang Ying Yin Wencheng Song Mengru Xie Shaoling Yu Lili Chen 

机构地区：[1]Department of Stomatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [2]School of Stomatology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [3]Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration,Wuhan,China [4]Department of Stomatology,The First Affiliated Hospital,School of Medicine,Shihezi University,Shihezi,China

出　　处：《International Journal of Oral Science》2024年第2期322-332,共11页国际口腔科学杂志（英文版）

基　　金：funded by the National Natural Science Foundation of China for Key Program Projects(No.82030070,to L.C.);Hubei Provincial Natural Science Fund for Creative Research(No.2020CFA014,to L.C.);the National Natural Science Foundation of China(No.82100960,to S.Y.);Chinese Orthodontic Society Basic Research Fund(COS-B2021-01,to M.X.).

摘　　要：The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic treatment.However,the sensitivity of existing detection techniques is not sufficient,and the criteria for evaluating optimal force have not been yet established.Here,by employing 3D finite element analysis methodology,we found that the apical distal region(A-D region)of mesial roots is particularly sensitive to orthodontic force in rats.Tartrate-resistant acidic phosphatase(TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams(g),leading to alveolar bone resorption and tooth movement.When the force reached 80 g,TRAP-positive osteoclasts started appearing on the root surface in the A-D region.Additionally,micro-computed tomography revealed a significant root resorption at 80 g.Notably,the A-D region was identified as a major contributor to whole root resorption.It was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement,inclination,and hyalinization.These findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat model.Collectively,our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients’orthodontic treatment.

关 键 词：MOVEMENT ROOTS offering 

分 类 号：R783.5[医药卫生—口腔医学]