基于蛋白质能量与微量营养素分析对阿尔茨海默病营养状况与认知功能关联的研究  

The present study investigates the association between nutritional status and cognitive function in individuals with Alzheimer's disease,focusing on protein energy and micronutrients

作　　者：颜靖文 罗峥 张燕 张蔚 陆瑞峰 郭锦荣 蒋思佳 顾耘[3] Jingwen YAN;Zheng LUO;Yan ZHANG;Wei ZHANG;Ruifeng LU;Jinrong GUO;Sijia JIANG;Yun GU(Department of Traditional Chinese Medicine,Zhoupu Hospital Affiliated to Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;Department of neurology,Zhoupu Hospital Affiliated to Shanghai University of Medicine&Health Sciences,Shanghai 201318,China;Department of geriatrics,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海健康医学院附属周浦医院中医科,上海201318 [2]上海健康医学院附属周浦医院神经内科,上海201318 [3]上海中医药大学附属龙华医院老年科,上海200032

出　　处：《阿尔茨海默病及相关病杂志》2024年第3期184-189,共6页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：上海市浦东新区卫生健康委员会优秀青年医学人才培养项目(PWRq2020-54);上海市浦东新区卫生健康委员会中西医协同旗舰医院(YC-2023-0401);2022年上海市名老中医学术经验研究工作室建设项目(SHGZS-202241)。

摘　　要：目的:从蛋白质能量和微量营养素水平探讨阿尔茨海默病(Alzheimer's disease,AD)患者的营养状况,并分析其与认知功能的相关性。方法:根据纳入排除标准选取AD患者100例,另选取同期非AD患者100例作为对照组。根据CDR评分,将AD组分为轻度AD组(34例),中度AD组(32例),重度AD组(34例)。观察各组患者蛋白质能量以及微量营养素水平,分析影响AD进展的相关营养因素。结果:与对照组比较,AD组的BMI、MNA-SF、ALB、HGB、FA、25-(OH)D3、TC、TG显著降低,MMA、HCY显著升高(P均<0.05)。MNA-SF、HGB、FA从轻度AD组到中度AD组到重度AD组呈降低趋势,MMA呈升高趋势(P均<0.05)。重度AD组的BMI、ALB偏低,轻度AD组HCY偏低、25-(OH)D3偏高(P均<0.05)。Logistic回归分析显示,MNA-SF、FA与AD发展程度相关(P均<0.05)。结论:AD患者的总体营养状况较差,并随AD严重程度增加其蛋白质能量以及微量营养素水平下降。Objective:The objective of this study is to examine the nutritional status of individuals diagnosed with Alzheimer's disease by assessing protein energy and micronutrient levels,and subsequently analyze its association with cognitive function.Methods:According to the predefined inclusion and exclusion criteria,a total of 100 patients diagnosed with Alzheimer's disease and an equal number of non-AD patients were meticulously selected as the control group.Based on the CDR score,the AD group was stratified into three subgroups:mild(34 cases),moderate(32 cases),and severe(34 cases)AD groups.The protein energy,and micronutrient levels of each group were assessed,and an analysis was conducted on the relevant nutritional factors influencing the progression of AD.Results:Compared to the control group,the AD group exhibited significant reductions in BMI,MNA-SF,ALB,HGB,FA,25-(OH)D3,TC and TG levels;meanwhile,MMA and HCY levels were significantly elevated(all P<0.05).The levels of NNA-SF,HGB,and FA exhibited a declining trend across the mild AD group,moderate AD group,and severe AD group,whereas MMA demonstrated an increasing trend(all P<0.05).The severe AD group exhibited lower levels of BMI and ALB,while the mild AD group showed lower levels of HCY and 25-(OH)D3(all P<0.05).The logistic regression analysis revealed significant correlations betweenMNA-SF,and FA with the degree of AD development(all P<0.05).Conclusion:The nutritional status of patients with Alzheimer's disease(AD)is generally poor,and there is a progressive.

关 键 词：阿尔茨海默病 营养 蛋白质能量 微量营养素 

分 类 号：R749.16[医药卫生—神经病学与精神病学]