Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson’s Disease  

作　　者：Jiaqi Niu Yan Zhong Chentao Jin Peili Cen Jing Wang Chunyi Cui Le Xue Xingyue Cui Mei Tian Hong Zhang 

机构地区：[1]Department of Nuclear Medicine and PET Center,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,310009,China [2]Institute of Nuclear Medicine and Molecular Imaging,Zhejiang University,Hangzhou,310009,China [3]Key Laboratory of Medical Molecular Imaging of Zhejiang Province,Hangzhou,310009,China [4]College of Biomedical Engineering&Instrument Science,Zhejiang University,Hangzhou,310014,China [5]Key Laboratory for Biomedical Engineering of Ministry of Education,Zhejiang University,Hangzhou,310014,China [6]Huashan Hospital and Human Phenome Institute,Fudan University,Shanghai,200040,China

出　　处：《Neuroscience Bulletin》2024年第6期743-758,共16页神经科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC2009900,2021YFE0108300,2022YFE0118000,and 2021YFA1101700);the National Natural Science Foundation of China(82030049);Fundamental Research Funds for the Central Universities of China.

摘　　要：Parkinson’s disease(PD)is one of the most common neurodegenerative diseases with a complex pathogenesis.Aggregations formed by abnormal deposition of alpha-synuclein(αSyn)lead to synapse dysfunction of the dopamine and non-dopamine systems.The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation.Positron emission tomography(PET),as a representative molecular imaging technique,enables the non-invasive visualization,characterization,and quantification of biological processes at cellular and molecular levels.Imaging synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical management.In this review,we focus on the synaptic dysfunction associated with theαSyn pathology of PD,summarize various related targets and radiopharmaceuticals,and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD.

关 键 词：Parkinson’s disease Positron emission tomography Synapse dysfunction ALPHA-SYNUCLEIN Dopamine system Non-dopamine system 

分 类 号：R742.5[医药卫生—神经病学与精神病学]