The Mystery 40 Hz:Unraveling the Efficacy of Rhythmic Stimulation in Alzheimer's Disease  

作　　者：Yixuan Ku 

机构地区：[1]Guangdong Provincial Key Laboratory of Brain Function and Disease,Center for Brain and Mental Well-being,Department of Psychology,Sun Yat-sen University,Guangzhou,510006,China [2]Peng Cheng Laboratory,Shenzhen,518000,China

出　　处：《Neuroscience Bulletin》2024年第6期831-834,共4页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(32171082);the National Social Science Foundation of China(17ZDA323);the Neuroeconomics Laboratory of Guangzhou Huashang College(2021WSYS002);the Guangdong Philosophy and Social Science Foundation(GD22YYS16);the Leading Talent Program(31620016)at Sun Yat-sen University.

摘　　要：Promises and Challenges of Rhythmic Stimulation.Recent advances in research have made significant strides in understanding the potential of 40 Hz rhythmic optogenetic stimulation for the treatment of Alzheimer's disease(AD).A pivotal study conducted by Iaccarino et al.(2016)unveiled that targeted stimulation of interneurons at this specific frequency results in a remarkable reduction ofβ-amyloid levels in a mouse model of AD[1].

关 键 词：STIMULATION ALZHEIMER 

分 类 号：R749.16[医药卫生—神经病学与精神病学]