Flexible,high-density,laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy  

作　　者：Yafeng Liu Zhouheng Wang Yang Jiao Ying Chen Guangyuan Xu Yinji Ma Xue Feng 

机构地区：[1]Applied Mechanics Laboratory,Department of Engineering Mechanics,Tsinghua University,Beijing 100084,China [2]Laboratory of Flexible Electronics Technology,Tsinghua University,Beijing 100084,China [3]College of Artificial Intelligence,Southwest University,Chongqing 400715,China [4]Institute of Flexible Electronics Technology of THU,Jiaxing 314000,China [5]Qiantang Science and Technology Innovation Center,Hangzhou 310016,China [6]School of Artificial Intelligence,Beijing University of Posts and Telecommunications,Beijing 100876,China

出　　处：《Bio-Design and Manufacturing》2024年第4期388-398,共11页生物设计与制造（英文）

基　　金：support of the National Natural Science Foundation of China(Nos.U20A6001,12002190,11972207,and 11921002);the Fundamental Research Funds for the Central Universities,China(No.SWUKQ22029);the Chongqing Natural Science Foundation of China(No.CSTB2022NSCQ-MSX1635).

摘　　要：High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

关 键 词：Electrocorticogram(ECoG)electrode EPILEPSY High density High resolution Laminated structure 

分 类 号：R742.1[医药卫生—神经病学与精神病学] TN911.7[医药卫生—临床医学]