血清SFRP1、DKK1在口腔颌面部间隙感染患者中的水平及其对预后不良的预测价值  

Levels of serum SFRP1 and DKK1 in patients with oral and maxillofacial space infection and their predictive value for poor prognosis

作　　者：毛玮刚 陈晓波 刘南霞 MAO Weigang;CHEN Xiaobo;LIU Nanxia(Department of Stomatology,Linfen Central Hospital,Linfen,Shanxi 041000,China)

机构地区：[1]山西省临汾市中心医院口腔科,山西临汾041000

出　　处：《检验医学与临床》2024年第15期2274-2278,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨分泌型卷曲相关蛋白1(SFRP1)、分泌型糖蛋白Dickkopf1(DKK1)在口腔颌面部间隙感染患者中的水平及其对预后不良的预测价值。方法选取2019年1月至2021年12月该院收治的120例口腔颌面部间隙感染患者作为研究对象,根据预后分为预后不良组和预后良好组。病原菌鉴定采用微生物鉴定仪;采用ELISA检测血清SFRP1、DKK1水平;采用受试者工作特征(ROC)曲线分析血清SFRP1、DKK1水平对口腔颌面部间隙感染患者预后不良的预测价值;采用多因素Logistic回归分析口腔颌面部间隙感染患者预后不良的影响因素。结果120例口腔颌面部间隙感染患者共检出50株病原菌,其中排前3位的病原菌依次为溶血性链球菌(40.00%)、大肠埃希菌(26.00%)、金黄色葡萄球菌(22.00%)。预后不良组血清SFRP1、DKK1水平均高于预后良好组,差异均有统计学意义(P<0.05)。年龄≥60岁、术后需在重症监护病房(ICU)监护、住院天数≥10 d的口腔颌面部间隙感染患者血清SFRP1、DKK1水平均高于年龄<60岁、术后无需在ICU监护、住院天数<10 d的患者,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,SFRP1、DKK1单独及2项指标联合检测预测口腔颌面部间隙感染患者预后不良的曲线下面积分别为0.788(95%CI:0.706~0.871)、0.773(95%CI:0.691~0.856)、0.872(95%CI:0.808~0.935)。多因素Logistic回归分析结果显示,血清SFRP1、DKK1水平升高是口腔颌面部间隙感染预后不良的危险因素(P<0.05)。结论血清SFRP1、DKK1对口腔颌面部间隙感染患者预后不良有重要预测价值,并且与患者年龄、术后需在ICU监护、住院天数均密切相关。Objective To investigate the levels of secreted frizzled-related protein 1(SFRP1)and secreted glycoprotein Dickkopf1(DKK1)in patients with oral and maxillofacial space infection and their predictive value for poor prognosis.Methods A total of 120 patients with oral and maxillofacial space infection admitted to the hospital from January 2019 to December 2021 were selected as the research objects.According to the prognosis,they were divided into a poor prognosis group and a good prognosis group.Pathogens were identified by microbial identification instrument,and serum SFRP1 and DKK1 levels were detected by ELISA.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum SFRP1 and DKK1 levels for the poor prognosis of patients with oral and maxillofacial space infection.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis of patients with oral and maxillofacial space infection.Results A total of 50 strains of pathogens were detected in 120 patients with oral and maxillofacial space infection,among which the top three pathogens were hemolytic Streptococcus(40.00%),Escherichia coli(26.00%),and Staphylococcus aureus(22.00%).The serum levels of SFRP1 and DKK1 in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).Age≥60 years old,the need in the intensive care unit(ICU)care,hospitalization days of 10 d or more oral and maxillofacial space infection patients serum SFRP1,DKK1 levels were higher than age<60 years old,without postoperative ICU guardianship,hospitalization days<10 d patients,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve of SFRP1,DKK1,SFRP1 and DKK1 alone or in combination for predicting poor prognosis of patients with oral and maxillofacial space infection was 0.788(95%CI:0.706-0.871),0.773(95%CI:0.691-0.856)and 0.872(95%CI:0.808-0.935)respectively.Multivariate Logistic regress

关 键 词：分泌型卷曲相关蛋白1 分泌型糖蛋白Dickkopf1 口腔颌面部间隙感染 预后不良 预测价值 

分 类 号：R782.3[医药卫生—口腔医学] R446.1[医药卫生—临床医学]