芝麻素酚生理活性功能研究进展  

Research advances in biological activities of sesaminol

作　　者：张祖姣 沈玉平 ZHANG Zujiao;SHEN Yuping(College of chemistry and bioengineering,Hunan University of Science and Engineering,Yongzhou 425199,China;Hunan Provincial Engineering Research Center for Ginkgo biloba,Yongzhou 425199,China;Hunan Engineering Research Center for Research and Development of Plant Resources in Nanling area,Yongzhou 425199,China)

机构地区：[1]湖南科技学院化学与生物工程学院,湖南永州425199 [2]湖南省银杏工程技术研究中心,湖南永州425199 [3]湖南南岭地区植物资源研究开发湖南省工程研究中心,湖南永州425199

出　　处：《食品与发酵工业》2024年第15期381-388,共8页Food and Fermentation Industries

基　　金：湖南省自然科学基金项目(2022JJ30273);湖南省教育厅科学研究项目(23A0585,22B0804);湖南省应用特色学科建设项目。

摘　　要：芝麻素酚是一种主要来源于芝麻的多酚类天然产物,具有多种生理活性功能以及很强的热稳定性,可作为药品、营养保健品以及化妆品添加剂,具有重要的应用和开发价值。近年来,研究者针对芝麻素酚开展了大量的研究。该文从抗氧化、抗炎、抗肿瘤、心血管保护、预防肥胖、神经保护和延缓皮肤衰老7个方面,综述了其最新研究进展,发现芝麻素酚生理活性功能和药理机制研究大多处于体外细胞模型或动物模型阶段,距离临床应用以及转化为市场产品仍有很长的距离,因此亟需深入推进研究。借助生命科学、现代医学和现代仪器分析技术的发展成果,深入研究药理作用机制,完善安全评价,发掘新的生理活性功能,将有助于促进芝麻素酚生理活性功能研究和相关产品开发。Sesaminol,a polyphenolic natural product primarily derived from Sesamum indicum,possesses multiple biological activities and strong thermostability.It can be utilized as a pharmaceutical,a nutritional supplement,and an additive in cosmetics,thus possessing great potential for application and development.In recent years,researchers have conducted extensive studies on sesaminol.This paper comprehensively reviews the latest research advances of sesaminol in seven aspects,including anti-oxidation,anti-inflammatory,anti-tumor,cardiovascular protection,obesity prevention,neuroprotection,and delaying skin aging.Most of the present studies focus on in vitro cell model or animal model,and there remains a considerable gap before clinical application and commercialization.Therefore,urgent advancement in research is required.Leveraging the advancements in life sciences,modern medicine,and modern instrumental analysis techniques,in-depth studies on pharmacological mechanisms,enhancement of safety assessment,and exploration of new physiological activities will facilitate the advancements of research on the biological activities of sesaminol and the development of associated products.

关 键 词：芝麻素酚 生理活性功能 抗氧化 制备方式 研究进展 

分 类 号：TS201.4[轻工技术与工程—食品科学]