Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma  

作　　者：Hongying Zhao Ying Liu Meiting Fei Lin Bo Lixia Wang Yaopeng Shu Peiqi Ben Li Wang 

机构地区：[1]College of Bioinformatics Science and Technology,Harbin Medical University,Harbin,Heilongjiang 150081,China

出　　处：《Genes & Diseases》2024年第5期51-54,共4页基因与疾病（英文）

基　　金：1the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province,China(No.UNPYSCT-2020174);the Excellent Youth Project of Provincial Scientific Research Institute(China)(No.CZKYF2022-1-C006);the Hei Long Jiang Postdoctoral Special Foundation(China)(No.LBH-TZ1018).

摘　　要：Glioblastoma(GBM)is the most common primary malignant intracranial tumor with a very poor prognosis.In this study,we systematically analyzed the DNA methylation alterations of autophagy-related lncRNAs and their association with drug therapies in GBM.We identified 9 DNA methylation-dysregulated lncRNA regulators of autophagy-related genes as autophagy-related lncRNAs.A dysregulated regulatory network consisting of 9 autophagy-related lncRNAs and 237 differentially expressed autophagy-related genes was constructed.Identification of small molecule drug candidates that may affect DNA methylation dysregulated lncRNA activity,including 45 drug lncRNA pairs,involving 7 DNA methylation dysregulated lncRNAs and 43 drugs.Furthermore,we identified a DNA methylation-dysregulated autophagy-related lncRNA MIR155HG as an independent prognostic indicator for GBM.

关 键 词：regulated alterations DRUGS 

分 类 号：R739.41[医药卫生—肿瘤]