Comprehensive analysis of mitochondrial dynamic-related genes on their functions and prognostic values for glioblastoma multiforme  

作　　者：Zhu Xie Wei Hua Hongyan Wang 

机构地区：[1]Shanghai Key Laboratory of Metabolic Remodeling and Health,Institute of Metabolism and Integrative Biology,Obstetrics and Gynecology Hospital,State Key Laboratory of Genetic Engineering,Fudan University,Shanghai 200433,China [2]Institute of Reproduction and Development,Shanghai Institute of Planned Parenthood Research,NHC Key Laboratory of Reproduction Regulation,Children’s Hospital,Fudan University,Shanghai 200433,China [3]Institutes of Biomedical Sciences,Huashan Hospital,Fudan University,Shanghai 200435,China

出　　处：《Genes & Diseases》2024年第5期78-80,共3页基因与疾病（英文）

基　　金：the Key R&D Program of the Science and Technology Ministry of China(No.2021YFC2701100);the National Natural Science Foundation of China(No.82150008,81930036);the Commission of Science and Technology of Shanghai Municipality,China(No.20JC1418500).

摘　　要：Glioblastoma multiforme(GBM)is the most malignant intracranial tumor in adults and its unique pathology leads to limited therapeutic benefits.1,2 Mitochondrial fusion and fission play an important role in carcinogenesis;fragmented mitochondria promote tumor cell proliferation and prolonged mitochondria lead to tumor cell apoptosis.3 Therefore,profiling the function and prognostic value of mitochondrial dynamics-related genes(MDRGs)is of great interest for GBM precision treatment.Here we focused on the expression,function,and genetic alterations of MDRGs and identified new DNA methylation sites being significantly associated with the survival of GBM patients using available data in public databases.

关 键 词：alterations MULTIFORME PATHOLOGY 

分 类 号：R739.41[医药卫生—肿瘤]