Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma  

作　　者：Zhiyi Wang Shuang Chen Dongxiao Li Hui Xu Siyuan Weng Yuyuan Zhang Yuqing Ren Chunguang Guo Xiuling Li Zaoqu Liu Xinwei Han 

机构地区：[1]Department of Interventional Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [2]Department of Gastroenterology,Henan Provincial People’s Hospital,Zhengzhou University People’s Hospital,Zhengzhou,Henan 450004,China [3]Center of Reproductive Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [4]Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [5]Department of Endovascular Surgery,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [6]State Key Laboratory of Proteomics,Beijing Proteome Research Center,National Center for Protein Sciences(Beijing),Beijing Institute of Lifeomics,Beijing 102206,China [7]State Key Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,Department of Pathophysiology,Peking Union Medical College,Beijing 100730,China

出　　处：《Genes & Diseases》2024年第5期81-84,共4页基因与疾病（英文）

摘　　要：Hepatocellular carcinoma(HCC)is a highly heterogeneous tumor,with dynamic equilibrium and complex interplay between its intricate tumor nature and ambient tumor immune microenvironment(TIME).1 Elegant research has indicated that cancer stem cells,a small subset of neoplastic cells confined within dedicated niches,display stem cell-like properties and interact with cells in TIME,thereby imparting an indelible impact on stemness regulation,tumor heterogeneity,and cancer cell plasticity.2 Previous taxonomies solely from the perspective of stemness or TIME may introduce some degree of bias in the comprehension of HCC carcinogenesis,3,4 and thus it is of paramount importance to systematically consider tumor stemness and TIME as a whole to truly portray the biological landscape of HCC.

关 键 词：thereby LANDSCAPE STEM 

分 类 号：R735.7[医药卫生—肿瘤]