MMP-9 deficiency accelerates the progress of periodontitis  

作　　者：Chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu Graham Goldman Li-An Wu Feng Wang Dao-Shu Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen Shuo Chen 

机构地区：[1]Department of Endodontics,The Affiliated Hospital of Qingdao University,School of Stomatology,Qingdao University,Qingdao,Shandong 266003,China [2]Department of Developmental Dentistry,School of Dentistry,The University of Texas Health Science Center at San Antonio,San Antonio,TX 78229,USA [3]Oral Implantology Center,Jinan Stomatological Hospital,Jinan,Shandong 250001,China [4]Department of Endodontics,School and Hospital of Stomatology,Cheeloo College of Medicine,Shandong Key Laboratory of Oral Tissue Regeneration,Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration,Shandong University,Jinan,Shandong 250012,China [5]Department of Pediatric Dentistry,School of Stomatology,The Fourth Military Medical University,Xi’an,Shaanxi 710032,China [6]Laboratory of Clinical Applied Anatomy,Department of Human Anatomy,School of Basic Medical Sciences,Fujian Medical University,Fuzhou,Fujian 350108,China [7]Key Laboratory for Oral Biomedical Research of Zhejiang Province,Affiliated Hospital of Stomatology,Medical College,Zhejiang University,Hangzhou,Zhejiang 310027,China [8]Department of Stomatology,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China [9]UBC Faculty of Dentistry,University of British Columbia,Vancouver,BC V6T 1Z3,Canada [10]School of Graduate Studies and Research,Meharry Medical College and Research Biologist,Research Service Nashville VA Medical Center,Nashville,TN 37208,USA [11]State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST),Key Laboratory for Oral Biomedicine of Ministry of Education(KLOBM),School and Hospital of Stomatology,Wuhan University,Wuhan,Hubei 430079,China

出　　处：《Genes & Diseases》2024年第5期117-121,共5页基因与疾病（英文）

基　　金：the National Institutes of Health grants,RO1DE019802;the Pilot Grant of the School of Dentistry,UTHSCSA,131314.

摘　　要：Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone resorption.Approximately one-half of adults in the United States older than 30 years have periodontal disease.2 Though the disease is initiated by bacterial infection,it activates host defense systems that eventually lead to the degradation of the periodontium.During periodontitis,the disease progress involves further production of pro-inflammatory mediators such as cytokines,proteolytic enzymes like matrix metalloproteinases(MMPs),and their inhibitors.

关 键 词：PERIOD eventually UNTREATED 

分 类 号：R781.42[医药卫生—口腔医学]