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作品数：134被引量：170H指数：7
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Alternating modified CAPOX/CAPIRI plus bevacizumab in untreated unresectable metastatic colorectal cancer:a phase 2 trial
《Signal Transduction and Targeted Therapy》2025年第1期321-327,共7页Sheng Li Xiaoyou Li Hanfeng Xu Jiayuan Huang Jingni Zhu Ying Peng Jun Bao Liangjun Zhu 
supported by Beijing Science and Technology Innovation Medical Development Foundation(grant no.KC2021-JX-0186-106).
Previous studies showed encouraging efficacy of alternating FOLFOX/FOLFIRI for metastatic colorectal cancer(mCRC).This phase 2 trial(NCT04324476)aimed to evaluate efficacy and safety of alternating modified CAPOX(cape...
关键词：BEVACIZUMAB UNTREATED COLORECTAL 
MMP-9 deficiency accelerates the progress of periodontitis
《Genes & Diseases》2024年第5期117-121,共5页Chun-Yan Wan Yixin Yin Xiaoyan Li Meng Meng Liu Graham Goldman Li-An Wu Feng Wang Dao-Shu Luo Zhuo Chen Wen-An Xu Stephen Chen Mary MacDougall Merry L.Lindsey Zhi Chen Shuo Chen 
the National Institutes of Health grants,RO1DE019802;the Pilot Grant of the School of Dentistry,UTHSCSA,131314.
Periodontitis is a chronic inflammatory disease caused by periodontopathic bacteria that affects periodontal support tissues.1 If left untreated,it results in loss of periodontal attachment and alveolar bone resorptio...
关键词：PERIOD eventually UNTREATED 
Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)
《Cancer Communications》2024年第9期1005-1017,共13页Shun Lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen Yuping Sun Yinghua Ji ZipingWang Jianhua Shi Junguo Lu Shaoshui Chen Dongqing Lv Guojun Zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie Hu Nong Yang Xiangdong Zhou XiaohongWu Chengping Hu Zhihong Zhang You Lu Yanping Hu Liyan Jiang Qiming wang Renhua Guo Jianying Zhou Baolan Li Chunhong Hu Wancheng Tong Helong Zhang LinMa Yuan Chen Zhijun Jie Yu Yao Longzhen Zhang JieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu 
Hansoh Pharmaceutical Group Co.Ltd;National Natural Science Foundation of China,Grant/Award Numbers:82030045,82241227;National Multi-disciplinary Treatment Project for Major Diseases,Grant/Award Number:2020NMDTP;Collaborative Innovation Center for Clinical and Translational Science by Ministry of Education&Shanghai,Grant/Award Numbers:CCTS-202204,CCTS-202304;Shanghai Chest Hospital Basic Research Project,Grant/Award Number:2023YNKT-1;Pujiang Program,Grant/Award Number:22PJ1420700。
Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal g...
关键词：aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI 
Nanoskin®-ACT—The Impact of Natural Membrane & Soft with Chronic and Untreated Wounds
《Journal of Biomaterials and Nanobiotechnology》2024年第3期39-50,共12页Saqer Al Mualla Noura Salim Salman Salma Saeed Ns. Nasreen Abdelatif Mohamed Kanjou Gabriel Molina de Olyveira Pierre Basmaji Antônio Carlos Guastaldi 
Bacterial cellulose (BC) is a versatile biomaterial with unique properties that make it promising for various biomedical applications, including wound healing. The extracellular matrix (ECM) plays a crucial role in wo...
关键词：Bacterial Cellulose BIOMATERIALS NANOMEDICINE Wound Healing Green Propolis and Usnic Acid 
Gefitinib(an EGFR tyrosine kinase inhibitor)plus anlotinib(an multikinase inhibitor)for untreated,EGFR-mutated,advanced non-small cell lung cancer(FL-ALTER):a multicenter phase III trial被引量：1
《Signal Transduction and Targeted Therapy》2024年第9期4091-4102,共12页Hua-Qiang Zhou Ya-Xiong Zhang Gang Chen Qi-Tao Yu Hua Zhang Guo-Wu Wu Di Wu Ying-Cheng Lin Jun-Fei Zhu Jian-Hua Chen Xiao-Hua Hu Bin Lan Ze-Qiang Zhou Hai-Feng Lin Zi-Bing Wang Xiao-Lin Lei Suo-Ming Pan Li-Ming Chen Jian Zhang Tian-Dong Kong Ji-Cheng Yao Xin Zheng Feng Li Li Zhang Wen-Feng Fang 
funded by the Chinese National Natural Science Foundation Project(Grant No.82173101,82373262,82241232,82272789,82102864);Guangzhou Basic and Applied Basic Research Foundation(2024A04J4082);partly funded by the 308 Clinical Research Foundation of Sun Yat-sen University Cancer Center.
Dual inhibition of vascular endothelial growth factor and epidermal growth factor receptor(EGFR)signaling pathways offers the prospect of improving the effectiveness of EFGR-targeted therapy.In this phase 3 study(Clin...
关键词：cancer lung treatment 
Theoretical Assessment of Environmental Factors and Untreated Infectious Individuals in the Transmission Dynamics of Buruli ulcer
《Applied Mathematics》2024年第8期477-498,共22页Codjo Cesaire Yadouleton Myriam Djoukwe Tapi Judicael Deguenon Ghislain Emmanuel Sopoh 
Buruli ulcer is the third most common mycobacterial disease worldwide, posing a significant public health burden, especially in impoverished regions of West and Central Africa, such as Benin. The management of Buruli ...
关键词：Buruli Ulcer Mathematical Models EQUILIBRIA STABILITY 
Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase
《World Journal of Hepatology》2024年第6期920-931,共12页De-Liang Huang Qin-Xian Cai Guang-De Zhou Hong Yu Zhi-Bin Zhu Jing-Han Peng Jun Chen 
Supported by Construction of Key Medical Disciplines in Shenzhen,No.SZXK076.
BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously conducted.AIM To assess the liver histological changes in the in...
关键词：Chronic hepatitis B Indeterminate phase Gray-zone Liver biopsy Pathological histology Risk factors 
Association between the frontoparietal network,clinical symptoms and treatment response in individuals with untreated anorexia nervosa
《General Psychiatry》2024年第3期364-374,共11页Qianqian He Hui Zheng Jialin Zhang Ling Yue Qing Kang Cheng Lian Lei Guo Yan Chen Yanran Hu Yuping Wang Sufang Peng Zhen Wang Qiang Liu Jue Chen 
supported by grants from Shanghai Jiao Tong University(YG2022ZD026);National Natural Science Foundation of China(81771461,82071545),Science and Technology Commission of Shanghai Municipality(20Y11906500);Shanghai Clinical Medical Research Center for Psychiatric and Psychological Disorders(19MC1911100);hospital-level research projects of Shanghai Mental Health Center(2020-YJ09,2020-QH-04);Youth Project of Shanghai Health Commission(20224Y0267).
Background Anorexia nervosa(AN)has been characterised as a psychiatric disorder associated with increased control.Currently,it remains difficult to predict treatment response in patients with AN.Their cognitive abilit...
关键词：SYMPTOMS ROUTINE PREVENTION 
XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2104-2113,共10页Qiu-Zhong Pan Jing-Jing Zhao Liang Liu Dong-Sheng Zhang Li-Ping Wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo Li Yan Tang Wei-Hong Zhang Jie-Yao Li Xiao Zheng Qi-Jing Wang Yong-Qiang Li Tong Xiang Li Zhou Shuang-Ning Yang Chen Wu Rong-Xing Huang Jia He Wei-Jiao Du Lu-Jun Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia 
This study was funded by the National Key R&D Program of China for J‐CX(grant number 2018YFC1313400);the National Natural Science Foundation of China for J.‐C.X.(grant number 81773110).We express our gratitude to all participating patients and their families,as well as to the study groups and investigators from the participating centers.
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains poor.This phase 3 trial(ClinicalTri...
关键词：PD1 immunotherapy BEVACIZUMAB 
Ensemble for evaluating diagnostic efficacy of non-invasive indices in predicting liver fibrosis in untreated hepatitis C virus population
《World Journal of Methodology》2024年第3期90-105,共16页Navneet Kaur Gitanjali Goyal Ravinder Garg Chaitanya Tapasvi Umit Demirbaga 
BACKGROUND Hepatitis C virus(HCV)infection progresses through various phases,starting with inflammation and ending with hepatocellular carcinoma.There are several invasive and non-invasive methods to diagnose chronic ...
关键词：Hepatitis C virus Non-invasive biomarkers Shear wave elastography FIBRONECTIN Bayesian network Machine learning Liver fibrosis 
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