CD147 facilitates cisplatin resistance in ovarian cancer through FOXM1 degradation inhibition  

作　　者：Miao Wang Lin Chen Yu Wang Tian Fan Chunyu Zhu Zhixian Li Lei Mou Hong Yang Airong Qian Yu Li 

机构地区：[1]School of Life Sciences,Northwestern Polytechnical University,Xi’an,Shaanxi 710072,China [2]Xi’an Key Laboratory of Stem Cell and Regenerative Medicine,Institute of Medical Research,Northwestern Polytechnical University,Xi’an,Shaanxi 710072,China [3]Department of Oncology,Air Force Medical Center,PLA,Beijing 100142,China [4]Department of Obstetrics and Gynecology,The First Affiliated Hospital of Air Force Medical University,Xi’an,Shaanxi 710032,China

出　　处：《Genes & Diseases》2024年第5期122-125,共4页基因与疾病（英文）

基　　金：the National Natural Science Foundation of China(No.81872129);Shaanxi Province University Joint Project(China)(No.2020GXLH-Y009);the Joint Research Funds of the Department of Science&Technology of Shaanxi Province and Northwestern Polytechnical University(China)(No.2020GXLH-Z013).

摘　　要：Currently,the major therapy for patients with ovarian cancer includes post-cytoreductive surgery followed by chemotherapy of carboplatin or cisplatin plus paclitaxel.The rise of drug resistance is a substantial factor in cancer recurrence and mortality among ovarian cancer patients receiving cisplatin treatment.CD147 is widely expressed in a variety of cancer tissues1 and recognized as a drug target for its antibody drug Licartin which has been approved by China’s National Medicines and Pharmaceutical Administration.2 Even though many studies reported that CD147 is involved in the cisplatin resistance of varieties of cancers,3 its mechanism remains unclear.In this investigation,we uncovered a distinctive mechanism by which CD147 regulates cisplatin resistance through the proteasomal degradation of the transcription factor FOXM1,which is associated with DNA damage repair,in ovarian cancer cells.Our results suggest that targeting CD147 may have therapeutic implications for increasing cisplatin efficiency in the management of ovarian cancer.

关 键 词：FOXM1 CISPLATIN CD147 

分 类 号：R737.31[医药卫生—肿瘤]