Macrophages in cardiovascular diseases:molecular mechanisms and therapeutic targets  

作　　者：Runkai Chen Hongrui Zhang Botao Tang Yukun Luo Yufei Yang Xin Zhong Sifei Chen Xinjie Xu Shengkang Huang Canzhao Liu 

机构地区：[1]Department of Cardiology,Laboratory of Heart Center,Heart Center,Translational Medicine Research Center,Zhujiang Hospital,Southern Medical University,253 Industrial Avenue,Guangzhou 510280,China [2]State Key Laboratory of Cardiovascular Disease,Fuwai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100037,China

出　　处：《Signal Transduction and Targeted Therapy》2024年第6期2598-2641,共44页信号转导与靶向治疗（英文）

基　　金：supported by grants from the National Students’Platform for Innovation and Entrepreneurship Training Program of China(No.202212121004 and No.202212121023);the Guangdong Students’Platform for Innovation and Entrepreneurship Training Program(No.S202212121074);supported by the National Natural Science Foundation of China(82170231,82370410);Guangdong Basic and Applied Basic Research Foundation(2023B1515020103).

摘　　要：The immune response holds a pivotal role in cardiovascular disease development.As multifunctional cells of the innate immune system,macrophages play an essential role in initial inflammatory response that occurs following cardiovascular injury,thereby inducing subsequent damage while also facilitating recovery.Meanwhile,the diverse phenotypes and phenotypic alterations of macrophages strongly associate with distinct types and severity of cardiovascular diseases,including coronary heart disease,valvular disease,myocarditis,cardiomyopathy,heart failure,atherosclerosis and aneurysm,which underscores the importance of investigating macrophage regulatory mechanisms within the context of specific diseases.Besides,recent strides in single-cell sequencing technologies have revealed macrophage heterogeneity,cell–cell interactions,and downstream mechanisms of therapeutic targets at a higher resolution,which brings new perspectives into macrophage-mediated mechanisms and potential therapeutic targets in cardiovascular diseases.Remarkably,myocardial fibrosis,a prevalent characteristic in most cardiac diseases,remains a formidable clinical challenge,necessitating a profound investigation into the impact of macrophages on myocardial fibrosis within the context of cardiac diseases.In this review,we systematically summarize the diverse phenotypic and functional plasticity of macrophages in regulatory mechanisms of cardiovascular diseases and unprecedented insights introduced by singlecell sequencing technologies,with a focus on different causes and characteristics of diseases,especially the relationship between inflammation and fibrosis in cardiac diseases(myocardial infarction,pressure overload,myocarditis,dilated cardiomyopathy,diabetic cardiomyopathy and cardiac aging)and the relationship between inflammation and vascular injury in vascular diseases(atherosclerosis and aneurysm).Finally,we also highlight the preclinical/clinical macrophage targeting strategies and translational implications.

关 键 词：DISEASES CARDIOVASCULAR THERAPEUTIC 

分 类 号：R54[医药卫生—心血管疾病]